Study drug regimen and dosing schedule
| Drugs . | Day 1 . | Day 2 . | Day 3 . |
|---|---|---|---|
| Fludarabine 40 mg/m2 oral | ● | ● | ● |
| Cyclophosphamide 250 mg/m2 oral | ● | ● | ● |
| Alemtuzumab subcutaneously | |||
| First cohort: 10 mg (10 patients) | + ● | + ● | + ● |
| Second cohort: 20 mg | + ● | + ● | + ● |
| Drugs . | Day 1 . | Day 2 . | Day 3 . |
|---|---|---|---|
| Fludarabine 40 mg/m2 oral | ● | ● | ● |
| Cyclophosphamide 250 mg/m2 oral | ● | ● | ● |
| Alemtuzumab subcutaneously | |||
| First cohort: 10 mg (10 patients) | + ● | + ● | + ● |
| Second cohort: 20 mg | + ● | + ● | + ● |
Anti-infective prophylaxis included the following: acyclovir 400 mg twice a day and trimethoprim sulfamethoxazole 1000 mg every other day (administered from the beginning until 6 months after treatment end).
● indicates day of administration.