Blood parameters in 54 patients before and after HU therapy
| . | Before HU° . | On HU°° . | P . |
|---|---|---|---|
| Mean (SD) . | Mean (SD) . | ||
| Age, y | 6.4 (3.6) | 9.5 (4.0) | |
| WBC count, ×109/L | 14.6 (5.8) | 9.1 (3.8) | <.001 |
| Neutrophil count, ×109/L | 7.3 (4.2) | 4.6 (3.3) | <.001 |
| Platelet count, ×109/L | 405.6 (118.9) | 320.1 (99.4) | <.001 |
| Hemoglobin level, g/dL | 7.5 (0.9) | 8.7 (1.1) | <.001 |
| Hematocrit, % | 22.4 (3.0) | 26.0 (3.5) | <.001 |
| MCV, flt | 80.4 (9.5) | 97.6 (13.7) | <.001 |
| Reticulocyte count, ×109/L | 303.4 (99.9) | 183.5 (86.8) | <.001 |
| HbF, % | 8.5 (5.0) | 16.4 (8.4) | <.001 |
| LDH, IU/L | 1090 (361) | 801 (313) | <.001 |
| Total bilirubin, μmol/L | 53.9 (38.4) | 42.1 (25.9) | .068 |
| . | Before HU° . | On HU°° . | P . |
|---|---|---|---|
| Mean (SD) . | Mean (SD) . | ||
| Age, y | 6.4 (3.6) | 9.5 (4.0) | |
| WBC count, ×109/L | 14.6 (5.8) | 9.1 (3.8) | <.001 |
| Neutrophil count, ×109/L | 7.3 (4.2) | 4.6 (3.3) | <.001 |
| Platelet count, ×109/L | 405.6 (118.9) | 320.1 (99.4) | <.001 |
| Hemoglobin level, g/dL | 7.5 (0.9) | 8.7 (1.1) | <.001 |
| Hematocrit, % | 22.4 (3.0) | 26.0 (3.5) | <.001 |
| MCV, flt | 80.4 (9.5) | 97.6 (13.7) | <.001 |
| Reticulocyte count, ×109/L | 303.4 (99.9) | 183.5 (86.8) | <.001 |
| HbF, % | 8.5 (5.0) | 16.4 (8.4) | <.001 |
| LDH, IU/L | 1090 (361) | 801 (313) | <.001 |
| Total bilirubin, μmol/L | 53.9 (38.4) | 42.1 (25.9) | .068 |
HbF indicates fetal hemoglobin; HR, hazard ratio; LDH, lactate dehydrogenase; MCV, mean corpuscular volume; and WBC, white blood cell count.