Comparison of quality of life
| Parameter . | Mean score* . | 95% CI for difference (%)† . | Interpretation‡ . | ||
|---|---|---|---|---|---|
| Surgery/CTx (n = 64) . | Chemotherapy (n = 11) . | Upper limit . | Lower limit . | ||
| Functional scales | |||||
| Physical functioning | 73.53 | 74.01 | 11.59 | −12.55 | Not inferior |
| Role functioning | 77.76 | 75.86 | 16.64 | −12.84 | Not inferior |
| Emotional functioning | 78.27 | 87.99 | 3.44 | −22.83 | Inferior |
| Cognitive functioning | 78.64 | 79.19 | 11.44 | −12.56 | Not inferior |
| Social functioning | 79.84 | 73.44 | 23.86 | −11.06 | Not inferior |
| Symptom scales | |||||
| Fatigue | 47.90 | 46.23 | 13.34 | −16.67 | Inferior |
| Nausea and vomiting | 1.50 | 0.01 | 5.05 | −8.79 | Not inferior |
| Pain | 6.52 | 14.50 | 25.14 | −9.19 | Not inferior |
| Dyspnea | 18.01 | 7.35 | 8.31 | −29.63 | Inferior |
| Insomnia | 8.95 | 5.90 | 17.16 | −23.27 | Inferior |
| Appetite loss | 20.40 | 24.42 | 20.31 | −12.47 | Not inferior |
| Constipation | 17.24 | 10.51 | 8.07 | −21.55 | Inferior |
| Diarrhea | 38.73 | 19.87 | 1.82 | −39.55 | Inferior |
| Financial difficulties | 21.08 | 28.38 | 26.64 | −12.24 | Not inferior |
| Global health status | |||||
| Global health | 61.31 | 71.50 | 6.02 | −26.38 | Inferior |
| Parameter . | Mean score* . | 95% CI for difference (%)† . | Interpretation‡ . | ||
|---|---|---|---|---|---|
| Surgery/CTx (n = 64) . | Chemotherapy (n = 11) . | Upper limit . | Lower limit . | ||
| Functional scales | |||||
| Physical functioning | 73.53 | 74.01 | 11.59 | −12.55 | Not inferior |
| Role functioning | 77.76 | 75.86 | 16.64 | −12.84 | Not inferior |
| Emotional functioning | 78.27 | 87.99 | 3.44 | −22.83 | Inferior |
| Cognitive functioning | 78.64 | 79.19 | 11.44 | −12.56 | Not inferior |
| Social functioning | 79.84 | 73.44 | 23.86 | −11.06 | Not inferior |
| Symptom scales | |||||
| Fatigue | 47.90 | 46.23 | 13.34 | −16.67 | Inferior |
| Nausea and vomiting | 1.50 | 0.01 | 5.05 | −8.79 | Not inferior |
| Pain | 6.52 | 14.50 | 25.14 | −9.19 | Not inferior |
| Dyspnea | 18.01 | 7.35 | 8.31 | −29.63 | Inferior |
| Insomnia | 8.95 | 5.90 | 17.16 | −23.27 | Inferior |
| Appetite loss | 20.40 | 24.42 | 20.31 | −12.47 | Not inferior |
| Constipation | 17.24 | 10.51 | 8.07 | −21.55 | Inferior |
| Diarrhea | 38.73 | 19.87 | 1.82 | −39.55 | Inferior |
| Financial difficulties | 21.08 | 28.38 | 26.64 | −12.24 | Not inferior |
| Global health status | |||||
| Global health | 61.31 | 71.50 | 6.02 | −26.38 | Inferior |
The mean scores for each parameter. The higher scores of functional scales and global health status indicate better function and health status. The lower scores of symptom scales indicate that patients have fewer symptoms.
The 95% CI for difference between 2 groups adjusting covariates, such as IPI, serum LDH concentration, B symptoms, involved sites, stage, age at diagnosis, survival time, and ECOG performance status.
If the lower limit of the 95% CI is within the margin of 15%, the parameter of surgery plus chemotherapy can be interpreted as not inferior to that of chemotherapy.