Mice immunized for the induction of EAE were treated from day 0 to day 30 after immunization with either carrier or the p38 MAPK inhibitor SB203580 (5 mg/kg/d). Animals were scored daily for clinical signs starting on day 10. Mean trait values ± SD are shown. The significance of the difference in incidence was determined by χ² test, and the significance of the differences in EAE-quantitative trait variables was determined using the independent samples t test within SPSS (Levene test for equality of variances and t test for equality of means). P values ≤ .05 are considered significant.

EAE indicates experimental allergic encephalomyelitis; DO, day of onset; CDS, cumulative disease score; PS, peak score; DA, days affected; and SI, severity index.