Ig gene sequence characteristics
| Case . | VH gene . | Homology/clones/ intraclonal variation (y/n) . | DH gene . | JH gene . | VH-CDR3 length . | VL gene . | Homology . | JL gene . |
|---|---|---|---|---|---|---|---|---|
| Case 10 | IGHV1-02*04 | 93.40/10/y | HD3-3*01 | HJ3*02 | 22 | IGKV3-20*01 | 92.91 | KJ2*01 |
| Case 25 | IGHV1-02*04 | 95.14/10/n | HD3-3*01 | HJ2*01 | 22 | IGKV1-17*01 | 97.49 | KJ1*01 |
| Case 103 | IGHV1-02*04 | 95.88/10/n | HD3-3*01 | HJ6*02 | 21 | IGKV1-17*01 | 97.13 | KJ1*01 |
| Case 129 | IGHV1-02*04 | 94.79/9/y | HD3-3*01 | HJ6*03 | 22 | IGKV1-27*01 | 94.44 | KJ4*01 |
| Case 152 | IGHV1-02*04 | 95.83/19/n | HD3-3*01 | HJ4*03 | 22 | IGKV1-9*01 | 96.70 | KJ4*01 |
| IGV4-1*01 | 94.95 | KJ2*02 | ||||||
| Case 255 | IGHV1-02*04 | 96.18/10/n | HD3-9*01 | HJ6*03 | 23 | GKV3-17*01 | 97.85 | KJ4*01 |
| Case . | VH gene . | Homology/clones/ intraclonal variation (y/n) . | DH gene . | JH gene . | VH-CDR3 length . | VL gene . | Homology . | JL gene . |
|---|---|---|---|---|---|---|---|---|
| Case 10 | IGHV1-02*04 | 93.40/10/y | HD3-3*01 | HJ3*02 | 22 | IGKV3-20*01 | 92.91 | KJ2*01 |
| Case 25 | IGHV1-02*04 | 95.14/10/n | HD3-3*01 | HJ2*01 | 22 | IGKV1-17*01 | 97.49 | KJ1*01 |
| Case 103 | IGHV1-02*04 | 95.88/10/n | HD3-3*01 | HJ6*02 | 21 | IGKV1-17*01 | 97.13 | KJ1*01 |
| Case 129 | IGHV1-02*04 | 94.79/9/y | HD3-3*01 | HJ6*03 | 22 | IGKV1-27*01 | 94.44 | KJ4*01 |
| Case 152 | IGHV1-02*04 | 95.83/19/n | HD3-3*01 | HJ4*03 | 22 | IGKV1-9*01 | 96.70 | KJ4*01 |
| IGV4-1*01 | 94.95 | KJ2*02 | ||||||
| Case 255 | IGHV1-02*04 | 96.18/10/n | HD3-9*01 | HJ6*03 | 23 | GKV3-17*01 | 97.85 | KJ4*01 |
Homology is given as the percentage of identical nucleic acids compared with the closest germline gene sequence. The length of the CDR3 regions was determined according to the IGMT numbering (http://imgt.cines.fr/). Case 152 displays 2 functionally rearranged immunoglobulin light chains.
DJ indicates IgH diversity gene; JH, IgH junction gene; JL, Ig light chain junction gene; n, no; VH, IgH variable gene; VL, Ig light chain variable gene; and y, yes.