Table 2 Characteristics of MCL cell... | American Society of Hematology

Table 2

Characteristics of MCL cell lines

Cell line	P53 status*	Cyclin D1 expression†	Bz LC₅₀ at 24 h, nM	IPI-504 GI₅₀ at 72 h, μM
JVM-2	wt	+	7.6 ± 0.6	15.4 ± 0.04
Z-138	wt	+++	11.1 ± 0.3	0.4 ± 0.02
HBL-2	del/mut	++	14.1 ± 1.2	8.9 ± 0.02
Granta-519	wt	+++	6.9 ± 0.7	0.9 ± 0.08
Jeko-1	del/mut	+++	11.9 ± 0.8	10.8 ± 0.09
Rec-1	wt	+++	21.6 ± 2.3	15.0 ± 0.04
Maver	del/mut	+	18.8 ± 2.7	4.8 ± 0.03
UPN-1	del/mut	+++	6.7 ± 0.3	0.9 ± 0.02
Mino	del/mut	+	150 ± 0.9	1.4 ± 0.01
JBR	del/mut	+++	72.2 ± 1.2	9.2 ± 0.06
ZBR	wt	+++	36.2 ± 0.9	0.5 ± 0.01

Cell line	P53 status*	Cyclin D1 expression†	Bz LC₅₀ at 24 h, nM	IPI-504 GI₅₀ at 72 h, μM
JVM-2	wt	+	7.6 ± 0.6	15.4 ± 0.04
Z-138	wt	+++	11.1 ± 0.3	0.4 ± 0.02
HBL-2	del/mut	++	14.1 ± 1.2	8.9 ± 0.02
Granta-519	wt	+++	6.9 ± 0.7	0.9 ± 0.08
Jeko-1	del/mut	+++	11.9 ± 0.8	10.8 ± 0.09
Rec-1	wt	+++	21.6 ± 2.3	15.0 ± 0.04
Maver	del/mut	+	18.8 ± 2.7	4.8 ± 0.03
UPN-1	del/mut	+++	6.7 ± 0.3	0.9 ± 0.02
Mino	del/mut	+	150 ± 0.9	1.4 ± 0.01
JBR	del/mut	+++	72.2 ± 1.2	9.2 ± 0.06
ZBR	wt	+++	36.2 ± 0.9	0.5 ± 0.01

Bz indicates bortezomib; wt, wild-type; del, deleted; and mut, mutated.

Assessed by fluorescent in situ hybridization and direct sequencing.

Assessed by quantitative reverse transcription PCR.