Kinases and phosphatases responsible for the hyperphosphorylation of autoantigenic targets of paraproteins
| Paratarg . | Ag . | Type of Ag . | Phosphorylation . | PKCζ . | PP2A . |
|---|---|---|---|---|---|
| 1 | Cylicin 2 | Alloantigen | nd | nd | nd |
| 2 | TPP2 | Autoantigen | + | ∅ | + |
| 3 | IGFBP-2 | Autoantigen | nd | nd | nd |
| 4 | Porcine kinesin | Heteroantigen | nd | nd | nd |
| 5 | Microtubuli-associated protein | Autoantigen | + | + | + |
| 6 | LAPTM5 | Autoantigen | + | + | + |
| 7 | SLP-2 | Autoantigen | + | + | + |
| 8 | ATG13 | Autoantigen | + | + | + |
| 9 | RSP16 | Autoantigen | nd | + | + |
| 10 | SPAG7 | Autoantigen | + | ∅ | + |
| 11 | SIVA | Autoantigen | + | + | + |
| Paratarg . | Ag . | Type of Ag . | Phosphorylation . | PKCζ . | PP2A . |
|---|---|---|---|---|---|
| 1 | Cylicin 2 | Alloantigen | nd | nd | nd |
| 2 | TPP2 | Autoantigen | + | ∅ | + |
| 3 | IGFBP-2 | Autoantigen | nd | nd | nd |
| 4 | Porcine kinesin | Heteroantigen | nd | nd | nd |
| 5 | Microtubuli-associated protein | Autoantigen | + | + | + |
| 6 | LAPTM5 | Autoantigen | + | + | + |
| 7 | SLP-2 | Autoantigen | + | + | + |
| 8 | ATG13 | Autoantigen | + | + | + |
| 9 | RSP16 | Autoantigen | nd | + | + |
| 10 | SPAG7 | Autoantigen | + | ∅ | + |
| 11 | SIVA | Autoantigen | + | + | + |
PKC indicates phosphokinase C; PP2A, phosphatase 2A; nd, no material available or patient did not sign informed consent for this experiment; and ∅, no specific coimmunoprecipitate with anti-PKCζ Ab.