MicroRNAs with a documented functional role in myeloid leukemogenesis
| microRNA . | Location . | Expression . | Regulated by . | Targets . | In vitro effects . | In vivo effects . |
|---|---|---|---|---|---|---|
| miR-155 | 21q21.3 | Up-regulated in FLT3-ITD21,22,39 | NFκB8 | SHIP1, CEBPB91,92 | Blocks megakaryopoiesis93 Induces myeloid colonies | Induces myeloproliferation with MDS changes in mice71 |
| miR-196b | 7p15 | Up-regulated in t(11q23)/MLL36,38 | MLL38 | HOXB8 | Increases cell survival and proliferation of progenitors38 | |
| miR-223 | Xq12 | Down-regulated in t(8;21)94 | RUNX1/RUNX1T1, CEBPA, NFIA1,94 | MEF2C95 | Induces granulocytic differentiation95 | Granulocytosis in miR-223 KO mice95 |
| miR-29b-1 | 7q32 | Down-regulated in wild-type NPM1, t(11q23)/MLL and −7 and del(7q)22,96,97 | NFκB, MYC, YY16 | MCL1, CDK6, SP1, DNMT3A/B13,97,98 | Induces apoptosis97,98 Inhibits proliferation97,98 Regulates negatively DNA methylation13 | Reduces tumorigenicity97 |
| microRNA . | Location . | Expression . | Regulated by . | Targets . | In vitro effects . | In vivo effects . |
|---|---|---|---|---|---|---|
| miR-155 | 21q21.3 | Up-regulated in FLT3-ITD21,22,39 | NFκB8 | SHIP1, CEBPB91,92 | Blocks megakaryopoiesis93 Induces myeloid colonies | Induces myeloproliferation with MDS changes in mice71 |
| miR-196b | 7p15 | Up-regulated in t(11q23)/MLL36,38 | MLL38 | HOXB8 | Increases cell survival and proliferation of progenitors38 | |
| miR-223 | Xq12 | Down-regulated in t(8;21)94 | RUNX1/RUNX1T1, CEBPA, NFIA1,94 | MEF2C95 | Induces granulocytic differentiation95 | Granulocytosis in miR-223 KO mice95 |
| miR-29b-1 | 7q32 | Down-regulated in wild-type NPM1, t(11q23)/MLL and −7 and del(7q)22,96,97 | NFκB, MYC, YY16 | MCL1, CDK6, SP1, DNMT3A/B13,97,98 | Induces apoptosis97,98 Inhibits proliferation97,98 Regulates negatively DNA methylation13 | Reduces tumorigenicity97 |