Histomorphometric bone parameters for wild-type (Wt) and Crebbp+/− mice
| . | Genotype . | BV/TV, % . | Trabecular no/ROI . | Trabecular thickness, mm . | Trabecular separation, mm . | Osteoblasts, no/ROI . | Osteoblast, no/mm bone surface . | Mineral apposition rate, μm/d . | Bone formation rate, μm3/μm2/d . |
|---|---|---|---|---|---|---|---|---|---|
| Average ± SD | Wt | 9.23 ± 3.02 | 2.50 ± 0.88 | 0.039 ± 0.011 | 0.411 ± 0.179 | 39.8 ± 14.2 | 14.8 ± 5.8 | 0.610 ± 0.332 | 66.4 ± 60.9 |
| Crebbp+/− | 2.12 ± 1.91 | 1.00 ± 0.69 | 0.019 ± 0.006 | 1.686 ± 1.488 | 18.0 ± 7.9 | 19.6 ± 8.1 | 0.627 ± 0.291 | 44.3 ± 24.8 | |
| Range | Wt | 7.45-14.9 | 1.32-3.66 | 0.026-0.057 | 0.232-0.704 | 25-63 | 7.8-23.3 | 0.300-1.01 | 20.5-164.6 |
| Crebbp+/− | 0.44-4.75 | 0.24-1.88 | 0.011-0.025 | 0.505-4.122 | 9-29 | 11.9-32.3 | 0.300-1.012 | 13.6-82.5 | |
| P < .01 | P < .05 | P < .01 | P < .05 | P < .05 | NS | NS | NS |
| . | Genotype . | BV/TV, % . | Trabecular no/ROI . | Trabecular thickness, mm . | Trabecular separation, mm . | Osteoblasts, no/ROI . | Osteoblast, no/mm bone surface . | Mineral apposition rate, μm/d . | Bone formation rate, μm3/μm2/d . |
|---|---|---|---|---|---|---|---|---|---|
| Average ± SD | Wt | 9.23 ± 3.02 | 2.50 ± 0.88 | 0.039 ± 0.011 | 0.411 ± 0.179 | 39.8 ± 14.2 | 14.8 ± 5.8 | 0.610 ± 0.332 | 66.4 ± 60.9 |
| Crebbp+/− | 2.12 ± 1.91 | 1.00 ± 0.69 | 0.019 ± 0.006 | 1.686 ± 1.488 | 18.0 ± 7.9 | 19.6 ± 8.1 | 0.627 ± 0.291 | 44.3 ± 24.8 | |
| Range | Wt | 7.45-14.9 | 1.32-3.66 | 0.026-0.057 | 0.232-0.704 | 25-63 | 7.8-23.3 | 0.300-1.01 | 20.5-164.6 |
| Crebbp+/− | 0.44-4.75 | 0.24-1.88 | 0.011-0.025 | 0.505-4.122 | 9-29 | 11.9-32.3 | 0.300-1.012 | 13.6-82.5 | |
| P < .01 | P < .05 | P < .01 | P < .05 | P < .05 | NS | NS | NS |
P values shown are for the average values (n = 4). ROI indicates region of interest; and NS, not significant.