Characteristics of patients
Median age, y (range) | 47 (18-70) |
Sex | |
Male | 25 |
Female | 18 |
Type of disease | |
Hodgkin disease | 15 |
Non-Hodgkin lymphoma | 28 |
Diffuse large B-cell lymphoma | 15 |
Anaplastic B-cell lymphoma | 2 |
Grade III B follicular lymphoma | 3 |
Mantle cell lymphoma | 5 |
T-cell–rich B-cell lymphoma | 3 |
Median lines of previous therapy (not comprising salvage therapy before transplantation) | 2 (2-5) |
Previous therapies (detailed) | |
Hodgkin lymphoma patients | 15 |
ABVD | 6 |
MOPP | 9 |
BEACOPP | 8 |
IEV | 7 |
IGEV | 8 |
BEAM + ASCT | 3 |
Non-Hodgkin lymphoma patients | 28 |
R-CHOP (14 or 21) | 19 |
R-MegaCHOP | 4 |
R-MACOP-B | 5 |
R-MAD | 3 |
R-ESHAP | 5 |
R-DHAP | 11 |
R-IEV | 15 |
Cyclophosphamide 7 g/m2 | 2 |
DEXA-BEAM | 2 |
Disease stage | |
II | 7 |
III | 16 |
IV | 20 |
IPI score (NHL only) | |
Intermediate-high | 7 |
High | 21 |
Bulky disease? | |
Yes | 21 |
No | 22 |
Disease status at enrolment | |
Primary refractory | 21 |
Relapse | 22 |
Disease status before transplantation | |
Second or further complete remission, n (%) | 16 (37) |
Partial response, n (%) | 20 (46) |
No response/progression, n (%) | 7 (17) |
Median age, y (range) | 47 (18-70) |
Sex | |
Male | 25 |
Female | 18 |
Type of disease | |
Hodgkin disease | 15 |
Non-Hodgkin lymphoma | 28 |
Diffuse large B-cell lymphoma | 15 |
Anaplastic B-cell lymphoma | 2 |
Grade III B follicular lymphoma | 3 |
Mantle cell lymphoma | 5 |
T-cell–rich B-cell lymphoma | 3 |
Median lines of previous therapy (not comprising salvage therapy before transplantation) | 2 (2-5) |
Previous therapies (detailed) | |
Hodgkin lymphoma patients | 15 |
ABVD | 6 |
MOPP | 9 |
BEACOPP | 8 |
IEV | 7 |
IGEV | 8 |
BEAM + ASCT | 3 |
Non-Hodgkin lymphoma patients | 28 |
R-CHOP (14 or 21) | 19 |
R-MegaCHOP | 4 |
R-MACOP-B | 5 |
R-MAD | 3 |
R-ESHAP | 5 |
R-DHAP | 11 |
R-IEV | 15 |
Cyclophosphamide 7 g/m2 | 2 |
DEXA-BEAM | 2 |
Disease stage | |
II | 7 |
III | 16 |
IV | 20 |
IPI score (NHL only) | |
Intermediate-high | 7 |
High | 21 |
Bulky disease? | |
Yes | 21 |
No | 22 |
Disease status at enrolment | |
Primary refractory | 21 |
Relapse | 22 |
Disease status before transplantation | |
Second or further complete remission, n (%) | 16 (37) |
Partial response, n (%) | 20 (46) |
No response/progression, n (%) | 7 (17) |
ABVD indicates adriamycin, bleomycin, vinblastine, and dacarbazine; ASCT, autologous stem cell transplantation; BEACOPP, cyclophosphamide, doxorubicin, etoposide, procarbazine, prenisone, bleomycin, and vincristine; BEAM, bendamustine,etoposide, cytarabine, and melphalan; DEXA-BEAM, dexamethasone, carmustine, etoposide, cytarabine, and melphalan; IEV, ifosfamide, epirubicin, and etoposide; IGEV, Ifosfamide, gemcitabine, and vinorelbine; IPI, International Prognostic Index; MOPP, mechlorethamine, oncovin, procarbazine, and prednisone; NHL, non-Hodgkin lymphoma; R-CHOP, rituximab, vincristine, doxorubicin, hydrochloride, cyclophosphomide, prednisone; R-DHAP, rituximab, dexamethasone, high-dose cytarabine, cisplatin; R-ESHAP, rituximab, etoposide, methylprednisolone, cytarabine, cisplatin; R-IEV, rituximab, ifosfamide, epirubicin, and etoposide; R-MACOP-B, rituximab, vincristine, doxorubicin, hydrochloride, methotrexate, bleonycin, cyclophosphamide, and and prednisolone; R-MAD, rituximab-mitoxantrone-cytarabine-dexamethasone.