Table 7

Published guidelines/recommendations for the off-label use of recombinant human activated factor VII, including warfarin-associated coagulopathy

Society (year)Recommendations
SABM/UHC (2005)99  Appropriate for spontaneous or traumatic intracranial bleeding in patients on warfarin 
EU societies (2006)100  Patients on warfarin anticoagulation not addressed 
Northern Ireland (2007)101  If on-going significant hemorrhage after correction of clotting factor deficiencies 
ASH (2008)94  Not indicated 
Society (year)Recommendations
SABM/UHC (2005)99  Appropriate for spontaneous or traumatic intracranial bleeding in patients on warfarin 
EU societies (2006)100  Patients on warfarin anticoagulation not addressed 
Northern Ireland (2007)101  If on-going significant hemorrhage after correction of clotting factor deficiencies 
ASH (2008)94  Not indicated 

SABM/UHC indicates Society for Advancement of Blood Management/University Hospitals Consortium; EU, European Union; and ASH, American Society of Hematology.

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