Polymorphisms associated with the incidence of stroke and validated in the SWiTCH and HUSTLE cohorts
| Gene . | SNP ID . | Minor allele . | HUSTLE (n = 206), % . | SWiTCH (n = 260), % . | Genetic model . | P . | Odds ratio . | 95% CI . |
|---|---|---|---|---|---|---|---|---|
| ADCY9 | rs2238432 | A | 33.0 | 22.3 | Dominant | .003 | 0.47 | 0.28-0.79 |
| ANXA2 | rs11853426 | T | 34.9 | 44.6 | Recessive | .007 | 2.70 | 1.25-5.84 |
| TEK | rs489347 | G | 35.9 | 46.9 | Recessive | .016 | 2.16 | 1.11-4.23 |
| TGFBR3 | rs284875 | T | 7.8 | 13.5 | Dominant | .005 | 2.53 | 1.28-4.99 |
| HbA2 | rs63751476 | Δ3.7 | 17.0 | 8.8 | Dominant | .009 | 0.45 | 0.24-0.84 |
| Gene . | SNP ID . | Minor allele . | HUSTLE (n = 206), % . | SWiTCH (n = 260), % . | Genetic model . | P . | Odds ratio . | 95% CI . |
|---|---|---|---|---|---|---|---|---|
| ADCY9 | rs2238432 | A | 33.0 | 22.3 | Dominant | .003 | 0.47 | 0.28-0.79 |
| ANXA2 | rs11853426 | T | 34.9 | 44.6 | Recessive | .007 | 2.70 | 1.25-5.84 |
| TEK | rs489347 | G | 35.9 | 46.9 | Recessive | .016 | 2.16 | 1.11-4.23 |
| TGFBR3 | rs284875 | T | 7.8 | 13.5 | Dominant | .005 | 2.53 | 1.28-4.99 |
| HbA2 | rs63751476 | Δ3.7 | 17.0 | 8.8 | Dominant | .009 | 0.45 | 0.24-0.84 |
The minor allele and the minor allele frequency are given for each SNP. Significance between the control (HUSTLE) and stroke (SWiTCH) groups was tested using Fisher exact test under the dominant or recessive genetic models. All SNPs matched the published orientation of association with stroke risk (increased or decreased risk) and were tested by a one-tailed Fisher exact test. The HbA2 polymorphism is the Δ3.7-kb α-thalassemia single gene deletion.