In vivo effect of R723 on JAK2 V617F–harboring cells
| . | Vehicle (n = 5) . | R723 (n = 5) . | ||
|---|---|---|---|---|
| Pretreatment . | Posttreatment . | Pretreatment . | Posttreatment . | |
| White blood cells, ×103/μL | 19.8 (10.8-28.5) | 19.8 (10.2-31.8) | 15.0 (11.7-25.2) | 10.8 (8.1-15.3)* |
| Mac-1+ or Gr-1+ myeloid, ×103/μL | 10.7 (3.2-19.2) | 11.4 (3.7-22.3) | 7.9 (6.4-20.2) | 4.6 (3.1-9.2)* |
| B220+ B cells, ×103/μL | 2.1 (0.4-9.6) | 2.0 (0.4-9.1) | 1.9 (0.8-5.1) | 2.5 (0.8-3.6) |
| CD4+ or CD8+ T cells, ×103/μL | 4.0 (3.0-7.2) | 2.8 (2.7-7.5) | 4.2 (3.4-4.7) | 3.6 (3.1-4.6) |
| CD45.1+ cells, ×103/μL | 1.5 (0.8-12.3) | 1.6 (0.7-11.2) | 1.5 (0.7-8.1) | 1.3 (0.7-4.4) |
| CD45.2+ cells, ×103/μL | 12.6 (2.6-27.7) | 13.0 (2.2-31.1) | 11.1 (6.9-24.5) | 7.4 (4.3-14.4)* |
| Hemoglobin, g/dL | 11.3 (11.2-13.9) | 11.1 (10.7-14) | 12.5 (11.2-14.5) | 12.9 (10.7-14.3) |
| Platelets, ×1010/L | 61.9 (50.8-81) | 53.2 (14-92.5) | 70.8 (52-119) | 106 (57.2-137) |
| Spleen weight, g | n.d. | 0.20 ± 0.04 | n.d. | 0.04 ± 0.01† |
| . | Vehicle (n = 5) . | R723 (n = 5) . | ||
|---|---|---|---|---|
| Pretreatment . | Posttreatment . | Pretreatment . | Posttreatment . | |
| White blood cells, ×103/μL | 19.8 (10.8-28.5) | 19.8 (10.2-31.8) | 15.0 (11.7-25.2) | 10.8 (8.1-15.3)* |
| Mac-1+ or Gr-1+ myeloid, ×103/μL | 10.7 (3.2-19.2) | 11.4 (3.7-22.3) | 7.9 (6.4-20.2) | 4.6 (3.1-9.2)* |
| B220+ B cells, ×103/μL | 2.1 (0.4-9.6) | 2.0 (0.4-9.1) | 1.9 (0.8-5.1) | 2.5 (0.8-3.6) |
| CD4+ or CD8+ T cells, ×103/μL | 4.0 (3.0-7.2) | 2.8 (2.7-7.5) | 4.2 (3.4-4.7) | 3.6 (3.1-4.6) |
| CD45.1+ cells, ×103/μL | 1.5 (0.8-12.3) | 1.6 (0.7-11.2) | 1.5 (0.7-8.1) | 1.3 (0.7-4.4) |
| CD45.2+ cells, ×103/μL | 12.6 (2.6-27.7) | 13.0 (2.2-31.1) | 11.1 (6.9-24.5) | 7.4 (4.3-14.4)* |
| Hemoglobin, g/dL | 11.3 (11.2-13.9) | 11.1 (10.7-14) | 12.5 (11.2-14.5) | 12.9 (10.7-14.3) |
| Platelets, ×1010/L | 61.9 (50.8-81) | 53.2 (14-92.5) | 70.8 (52-119) | 106 (57.2-137) |
| Spleen weight, g | n.d. | 0.20 ± 0.04 | n.d. | 0.04 ± 0.01† |
Peripheral blood data are presented as medians (range). Spleen weights are presented as means ± SE. The paired data between pretreatment and posttreatment were analyzed with a paired 2-tailed t test. The comparison of spleen weights between vehicle-treated mice and R723-treated mice were analyzed with a 2-tailed t test.
n.d. indicates no data.
P < .05.
P < .01.