R723 selectively inhibits JAK2
| Kinase . | IC50, nM . | Selectivity over JAK2, -fold . |
|---|---|---|
| JAK2 | 2 | NA |
| JAK1 | 740 | 370 |
| JAK3 | 26 | 13 |
| TYK2 | 3950 | > 500 |
| VEGFR2 | 1400 | > 500 |
| Syk | 300 | 150 |
| PKCa | 3960 | > 500 |
| PKCb1 | 7990 | > 500 |
| PKCd | > 10 000 | > 500 |
| PKCe | > 10 000 | > 500 |
| PKCq | > 10 000 | > 500 |
| PLK1 | > 10 000 | > 500 |
| RET | 109 | 55 |
| Kinase . | IC50, nM . | Selectivity over JAK2, -fold . |
|---|---|---|
| JAK2 | 2 | NA |
| JAK1 | 740 | 370 |
| JAK3 | 26 | 13 |
| TYK2 | 3950 | > 500 |
| VEGFR2 | 1400 | > 500 |
| Syk | 300 | 150 |
| PKCa | 3960 | > 500 |
| PKCb1 | 7990 | > 500 |
| PKCd | > 10 000 | > 500 |
| PKCe | > 10 000 | > 500 |
| PKCq | > 10 000 | > 500 |
| PLK1 | > 10 000 | > 500 |
| RET | 109 | 55 |