Table 3

CD36 SNPs showing strongest association with platelet CD36 expression level

SNPPositionA1/2Whites
Blacks
CAFβP*PP†CAFβP*PP†
rs3211870 21.384 G/A 0.42 0.55 0.000001.27 < 0.0001 0.44 1.30 0.005 0.217 
rs17154155 74.350 C/A 0.42 0.53 0.000001.63 < 0.0001 0.40 1.07 0.0256 0.517 
rs3211849 25.270 A/G 0.45 0.54 0.00000172 < 0.0001 0.52 1.47 0.000544 0.058 
rs1761662 70.130 G/A 0.46 0.52 0.00000176 < 0.0001 0.70 0.92 0.078 0.819 
rs7807607 81.708 G/A 0.45 0.51 0.00000211 < 0.0001 0.62 0.77 0.208 0.985 
rs3211842 25.957 G/A 0.43 0.53 0.00000218 < 0.0001 0.38 1.62 0.000287 0.041 
rs1358337 20.208 G/A 0.43 0.52 0.00000344 < 0.0001 0.50 1.54 0.0000456 0.014 
rs1761667 63.654 A/G 0.47 0.51 0.00000417 < 0.0001 0.54 1.83 0.0000276 0.011 
rs12706912 56.298 A/C 0.44 0.51 0.00000515 0.0001 0.48 1.39 0.0182 0.436 
rs1049654 33.138 C/A 0.46 0.50 0.00000560 0.0001 0.62 1.27 0.0131 0.371 
rs6960369 59.274 G/A 0.07 1.01 0.00000577 0.0001 0.27 0.24 0.74 1.000 
rs3211821 30.030 G/A 0.46 0.50 0.00000584 0.0001 0.70 1.01 0.0464 0.674 
rs4545029 56.075 C/A 0.47 0.50 0.00000659 0.0001 0.60 1.69 0.000147 0.028 
rs10480808 58.471 A/T 0.44 0.51 0.00000807 0.0003 0.44 1.65 0.000031 0.012 
rs10499859 49.783 G/A 0.47 0.50 0.00000921 0.0003 0.66 1.31 0.0269 0.530 
rs9784998 45.592 G/A 0.07 0.98 0.00000951 0.0003 0.24 1.43 0.0309 0.565 
rs3211817 30.486 A/C 0.07 0.98 0.00000951 0.0003 NA NA NA NA 
rs3211830 28.875 G/A 0.07 0.98 0.00000951 0.0003 0.10 0.09 0.95 1.000 
rs3211867 21.653 C/A 0.07 0.98 0.00000951 0.0003 0.24 1.43 0.0309 0.565 
rs1924 17.195 G/A 0.07 0.98 0.00000951 0.0003 0.28 0.99 0.151 0.954 
rs11971740 62.672 A/G 0.07 0.97 0.0000108 0.0004 0.26 0.93 0.19 0.978 
rs4731642 60.592 A/G 0.44 0.48 0.0000224 0.0005 0.12 0.62 0.38 1.000 
rs1534314 37.485 G/A 0.07 0.94 0.0000231 0.0005 0.24 1.43 0.0309 0.565 
rs9918586 41.857 A/G 0.07 0.90 0.0000429 0.0010 0.30 0.96 0.098 0.875 
rs3211869 21.441 T/A 0.06 0.96 0.000113 0.0031 0.16 1.97 0.00486 0.214 
rs1537593 54.682 G/A 0.09 0.73 0.000146 0.0035 0.36 1.50 0.00688 0.259 
rs3211883 19.550 T/A 0.10 0.69 0.000298 0.0064 0.54 0.20 0.684 1.000 
rs10499858 72.747 A/G 0.06 0.81 0.000478 0.0100 0.14 1.66 0.026 0.521 
rs11771839 79.372 C/A 0.06 0.80 0.000512 0.0104 0.14 1.66 0.026 0.521 
rs2065668 87.985 G/A 0.35 0.40 0.000765 0.0147 0.26 0.38 0.472 1.000 
rs3211908 14.677 G/A 0.05 0.78 0.00212 0.0379 NA NA NA NA 
SNPPositionA1/2Whites
Blacks
CAFβP*PP†CAFβP*PP†
rs3211870 21.384 G/A 0.42 0.55 0.000001.27 < 0.0001 0.44 1.30 0.005 0.217 
rs17154155 74.350 C/A 0.42 0.53 0.000001.63 < 0.0001 0.40 1.07 0.0256 0.517 
rs3211849 25.270 A/G 0.45 0.54 0.00000172 < 0.0001 0.52 1.47 0.000544 0.058 
rs1761662 70.130 G/A 0.46 0.52 0.00000176 < 0.0001 0.70 0.92 0.078 0.819 
rs7807607 81.708 G/A 0.45 0.51 0.00000211 < 0.0001 0.62 0.77 0.208 0.985 
rs3211842 25.957 G/A 0.43 0.53 0.00000218 < 0.0001 0.38 1.62 0.000287 0.041 
rs1358337 20.208 G/A 0.43 0.52 0.00000344 < 0.0001 0.50 1.54 0.0000456 0.014 
rs1761667 63.654 A/G 0.47 0.51 0.00000417 < 0.0001 0.54 1.83 0.0000276 0.011 
rs12706912 56.298 A/C 0.44 0.51 0.00000515 0.0001 0.48 1.39 0.0182 0.436 
rs1049654 33.138 C/A 0.46 0.50 0.00000560 0.0001 0.62 1.27 0.0131 0.371 
rs6960369 59.274 G/A 0.07 1.01 0.00000577 0.0001 0.27 0.24 0.74 1.000 
rs3211821 30.030 G/A 0.46 0.50 0.00000584 0.0001 0.70 1.01 0.0464 0.674 
rs4545029 56.075 C/A 0.47 0.50 0.00000659 0.0001 0.60 1.69 0.000147 0.028 
rs10480808 58.471 A/T 0.44 0.51 0.00000807 0.0003 0.44 1.65 0.000031 0.012 
rs10499859 49.783 G/A 0.47 0.50 0.00000921 0.0003 0.66 1.31 0.0269 0.530 
rs9784998 45.592 G/A 0.07 0.98 0.00000951 0.0003 0.24 1.43 0.0309 0.565 
rs3211817 30.486 A/C 0.07 0.98 0.00000951 0.0003 NA NA NA NA 
rs3211830 28.875 G/A 0.07 0.98 0.00000951 0.0003 0.10 0.09 0.95 1.000 
rs3211867 21.653 C/A 0.07 0.98 0.00000951 0.0003 0.24 1.43 0.0309 0.565 
rs1924 17.195 G/A 0.07 0.98 0.00000951 0.0003 0.28 0.99 0.151 0.954 
rs11971740 62.672 A/G 0.07 0.97 0.0000108 0.0004 0.26 0.93 0.19 0.978 
rs4731642 60.592 A/G 0.44 0.48 0.0000224 0.0005 0.12 0.62 0.38 1.000 
rs1534314 37.485 G/A 0.07 0.94 0.0000231 0.0005 0.24 1.43 0.0309 0.565 
rs9918586 41.857 A/G 0.07 0.90 0.0000429 0.0010 0.30 0.96 0.098 0.875 
rs3211869 21.441 T/A 0.06 0.96 0.000113 0.0031 0.16 1.97 0.00486 0.214 
rs1537593 54.682 G/A 0.09 0.73 0.000146 0.0035 0.36 1.50 0.00688 0.259 
rs3211883 19.550 T/A 0.10 0.69 0.000298 0.0064 0.54 0.20 0.684 1.000 
rs10499858 72.747 A/G 0.06 0.81 0.000478 0.0100 0.14 1.66 0.026 0.521 
rs11771839 79.372 C/A 0.06 0.80 0.000512 0.0104 0.14 1.66 0.026 0.521 
rs2065668 87.985 G/A 0.35 0.40 0.000765 0.0147 0.26 0.38 0.472 1.000 
rs3211908 14.677 G/A 0.05 0.78 0.00212 0.0379 NA NA NA NA 

All CD36 SNPs with PP values ≤ 0.05 using the white subset ordered by P value.

Position indicates base pair location using NCBI Build 37.p2, dbSNP Build 131; A1/2, allele 1/allele 2; CAF, coded allele, allele 2, frequency; β, SNP estimated regression coefficient from the linear regression of CD36 MFI on sex, first genetic principal component, and SNP, where SNP was coded as number of copies of allele 2; and NA, not applicable (SNP was dropped during QC filtering).

*

Genomic control-adjusted P value from F test of β = 0.

†

min-p permutation P value of β = 0 based on 10 000 permutations restricted to CD36 SNPs. Regressions fit separately for white and black subsets.

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