Table 2

SNPs showing strongest association with platelet CD36 expression in GWAS of whites

SNPChromosomePositionA1/2GeneCAFβP*q
rs3211870 80 287 209 G/A CD36 0.42 0.55 .00000127 0.012 
rs17154155 80 234 243 C/A CD36 0.42 0.53 .00000163 0.012 
rs3211849 80 283 323 A/G CD36 0.45 0.54 .00000172 0.012 
rs1761662 80 238 463 G/A CD36 0.46 0.52 .00000176 0.012 
rs7807607 80 226 885 G/A CD36 0.45 0.51 .00000211 0.012 
rs3211842 80 282 636 G/A CD36 0.43 0.53 .00000218 0.012 
rs1358337 80 288 385 G/A CD36 0.43 0.52 .00000394 0.015 
rs1761667 80 244 939 A/G CD36 0.47 0.51 .00000417 0.015 
rs2058703 60 679 226 A/G BCL11A 0.45 0.49 .00000423 0.015 
rs12706912 80 252 295 A/C CD36 0.44 0.51 .00000515 0.015 
rs1049654 80 275 455 C/A CD36 0.46 0.50 .00000560 0.015 
rs6960369 80 249 319 G/A CD36 0.07 1.01 .00000577 0.015 
rs3211821 80 278 563 G/A CD36 0.46 0.50 .00000584 0.015 
rs4545029 80 252 518 C/A CD36 0.47 0.50 .00000689 0.015 
rs10480808 80 250 122 A/T CD36 0.44 0.51 .00000807 0.015 
rs10499859 80 258 810 G/A CD36 0.47 0.50 .00000921 0.015 
rs9784998 80 263 001 G/A CD36 0.07 0.98 .00000951 0.015 
rs3211817 80 278 107 A/C CD36 0.07 0.98 .00000981 0.015 
rs3211830 80 279 718 G/A CD36 0.07 0.98 .00000951 0.015 
rs3211867 80 286 940 C/A CD36 0.07 0.98 .00000951 0.015 
rs1924 80 291 398 G/A CD36 0.07 0.98 .00000951 0.015 
rs11971740 80 245 921 A/G CD36 0.07 0.97 .00000108 0.017 
rs4731642 80 248 001 A/G CD36 0.44 0.48 .00000224 0.033 
rs1534314 80 271 108 G/A CD36 0.07 0.94 .00000231 0.033 
SNPChromosomePositionA1/2GeneCAFβP*q
rs3211870 80 287 209 G/A CD36 0.42 0.55 .00000127 0.012 
rs17154155 80 234 243 C/A CD36 0.42 0.53 .00000163 0.012 
rs3211849 80 283 323 A/G CD36 0.45 0.54 .00000172 0.012 
rs1761662 80 238 463 G/A CD36 0.46 0.52 .00000176 0.012 
rs7807607 80 226 885 G/A CD36 0.45 0.51 .00000211 0.012 
rs3211842 80 282 636 G/A CD36 0.43 0.53 .00000218 0.012 
rs1358337 80 288 385 G/A CD36 0.43 0.52 .00000394 0.015 
rs1761667 80 244 939 A/G CD36 0.47 0.51 .00000417 0.015 
rs2058703 60 679 226 A/G BCL11A 0.45 0.49 .00000423 0.015 
rs12706912 80 252 295 A/C CD36 0.44 0.51 .00000515 0.015 
rs1049654 80 275 455 C/A CD36 0.46 0.50 .00000560 0.015 
rs6960369 80 249 319 G/A CD36 0.07 1.01 .00000577 0.015 
rs3211821 80 278 563 G/A CD36 0.46 0.50 .00000584 0.015 
rs4545029 80 252 518 C/A CD36 0.47 0.50 .00000689 0.015 
rs10480808 80 250 122 A/T CD36 0.44 0.51 .00000807 0.015 
rs10499859 80 258 810 G/A CD36 0.47 0.50 .00000921 0.015 
rs9784998 80 263 001 G/A CD36 0.07 0.98 .00000951 0.015 
rs3211817 80 278 107 A/C CD36 0.07 0.98 .00000981 0.015 
rs3211830 80 279 718 G/A CD36 0.07 0.98 .00000951 0.015 
rs3211867 80 286 940 C/A CD36 0.07 0.98 .00000951 0.015 
rs1924 80 291 398 G/A CD36 0.07 0.98 .00000951 0.015 
rs11971740 80 245 921 A/G CD36 0.07 0.97 .00000108 0.017 
rs4731642 80 248 001 A/G CD36 0.44 0.48 .00000224 0.033 
rs1534314 80 271 108 G/A CD36 0.07 0.94 .00000231 0.033 

All SNPs with q value ≤ 0.05 using the white subset ordered by P value.

Position indicates base pair location using NCBI Build 37.p2, dbSNP Build 131; A1/2, allele 1/allele 2; CAF, coded allele, allele 2, frequency; and β, SNP estimated regression coefficient from the linear regression of CD36 MFI on sex, first genetic principal component, and SNP, where SNP was coded as number of copies of allele 2.

*

Genomic control-adjusted P value from F test of β = 0.

FDR q value from P value.

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