Table 2 Gene signatures of plasma-cell... | American Society of Hematology

Table 2

Gene signatures of plasma-cell differentiation in bortezomib-adapted MCL cell lines

Gene signature	HBL2 BR		JEKO BR
Gene signature	NES	FDR	NES	FDR
IRF4 high plasma cell vs B cell*	1.44	0.04	1.91	< 0.001
Plasma cell vs B cell*	1.52	0.08	1.65	0.03
Plasmablast high plasma cell low*	1.54	0.10	ns	ns
Plasma cell high plasmablast low*	ns	ns	1.69	0.03
BLIMP B cell repressed*	−2.48	< 0.001	ns	ns
Early differentiation genes†	−1.47	0.07	ns	ns

Gene signature	HBL2 BR		JEKO BR
Gene signature	NES	FDR	NES	FDR
IRF4 high plasma cell vs B cell*	1.44	0.04	1.91	< 0.001
Plasma cell vs B cell*	1.52	0.08	1.65	0.03
Plasmablast high plasma cell low*	1.54	0.10	ns	ns
Plasma cell high plasmablast low*	ns	ns	1.69	0.03
BLIMP B cell repressed*	−2.48	< 0.001	ns	ns
Early differentiation genes†	−1.47	0.07	ns	ns

GSEA was used to test for significant enrichment of defined plasma-cell differentiation signatures. NES indicates normalized enriched score; FDR, false discovery rate; and ns, not significant (FDR > 0.10).

Gene signatures of plasma cell differentiation were downloaded from http://lymphochip.nih.gov/signaturedb/index.html.³⁴

†

Gene signatures of plasma cell differentiation were extracted from the data of Zhan et al.³⁵

View Large

This Feature Is Available To Subscribers Only