IC50 of proteasome inhibitors and chemotherapeutic agents
| Drug . | HBL2 PT . | HBL2 BR . | Fold increase . | JEKO PT . | JEKO BR . | Fold increase . |
|---|---|---|---|---|---|---|
| Bortezomib, nM | 6 | 489.7 | 81.62 | 4.9 | 213.8 | 43.63 |
| MG-132, μM | 0.47 | 1.61 | 3.42 | 0.65 | 2.4 | 3.69 |
| NLVS, μM | 2 | 15.8 | 7.8 | 2.6 | 16.6 | 6.38 |
| Etoposide, μM | 1.25 | 0.60 | 0.48 | 3.8 | 1.9 | 0.50 |
| Fludarabine, μM | 1.9 | 0.65 | 0.34 | 0.7 | 0.45 | 0.64 |
| Hydrocortisone, μM | 60.25 | 44.67 | 0.74 | 87.09 | 25.12 | 0.29 |
| Drug . | HBL2 PT . | HBL2 BR . | Fold increase . | JEKO PT . | JEKO BR . | Fold increase . |
|---|---|---|---|---|---|---|
| Bortezomib, nM | 6 | 489.7 | 81.62 | 4.9 | 213.8 | 43.63 |
| MG-132, μM | 0.47 | 1.61 | 3.42 | 0.65 | 2.4 | 3.69 |
| NLVS, μM | 2 | 15.8 | 7.8 | 2.6 | 16.6 | 6.38 |
| Etoposide, μM | 1.25 | 0.60 | 0.48 | 3.8 | 1.9 | 0.50 |
| Fludarabine, μM | 1.9 | 0.65 | 0.34 | 0.7 | 0.45 | 0.64 |
| Hydrocortisone, μM | 60.25 | 44.67 | 0.74 | 87.09 | 25.12 | 0.29 |
IC50 was determined in triplicate by MTT at 48 hours of drug exposure.
NLVS indicates 4-hydroxy-5-iodo-3-nitrophenylacetyl-Leu-Leu-leucinal-vinyl sulfone.