Table 4 Results of multivariable... | American Society of Hematology

Table 4

Results of multivariable regression models for serum hepcidin concentrations (nM) stratified by sex

Variable	Men			Women
	β*	95% CI		β*	95% CI
	β*	Lower limit	Upper limit	β*	Lower limit	Upper limit
BMI, kg/m²†	NA	NA	NA	−0.042‡	−0.274	0.190
Ferritin, μg/L	0.779‡	0.740	0.818	0.830‡	0.783	0.877
Iron, μM	−0.005	−0.010	0.001	0.003	−0.003	0.009
TIBC, μM	−0.008	−0.012	−0.005	−0.005	−0.009	−0.001
ALT, U/L	NA	NA	NA	−0.111‡	−0.180	−0.043
eGFR, mL/min/1.73 m²	NA	NA	NA	−0.003	−0.005	−0.001
CRP
< 5 mg/L	Ref	Ref	Ref	Ref	Ref	Ref
5-20 mg/L	0.126	0.042	0.210	0.058	−0.030	0.147
> 20 mg/L	0.264	0.047	0.482	0.219	−0.023	0.462
Age, y	0.000	−0.004	0.004	−0.002	−0.007	0.002
Age, < 55 y vs ≥ 55 y	−0.101	−0.211	0.009	0.129	0.020	0.238
Time of blood sampling
Before 12 pm	Ref	Ref	Ref	Ref	Ref	Ref
Between 12 pm and 5 pm	0.336	0.264	0.409	0.389	0.303	0.474
After 5 pm	0.374	0.277	0.470	0.419	0.306	0.532

Variable	Men			Women
	β*	95% CI		β*	95% CI
	β*	Lower limit	Upper limit	β*	Lower limit	Upper limit
BMI, kg/m²†	NA	NA	NA	−0.042‡	−0.274	0.190
Ferritin, μg/L	0.779‡	0.740	0.818	0.830‡	0.783	0.877
Iron, μM	−0.005	−0.010	0.001	0.003	−0.003	0.009
TIBC, μM	−0.008	−0.012	−0.005	−0.005	−0.009	−0.001
ALT, U/L	NA	NA	NA	−0.111‡	−0.180	−0.043
eGFR, mL/min/1.73 m²	NA	NA	NA	−0.003	−0.005	−0.001
CRP
< 5 mg/L	Ref	Ref	Ref	Ref	Ref	Ref
5-20 mg/L	0.126	0.042	0.210	0.058	−0.030	0.147
> 20 mg/L	0.264	0.047	0.482	0.219	−0.023	0.462
Age, y	0.000	−0.004	0.004	−0.002	−0.007	0.002
Age, < 55 y vs ≥ 55 y	−0.101	−0.211	0.009	0.129	0.020	0.238
Time of blood sampling
Before 12 pm	Ref	Ref	Ref	Ref	Ref	Ref
Between 12 pm and 5 pm	0.336	0.264	0.409	0.389	0.303	0.474
After 5 pm	0.374	0.277	0.470	0.419	0.306	0.532

NA indicates not applicable; and Ref, reference category.

The dependent variable hepcidin was log-transformed before inclusion in the models. Thus, the β values express the changes in log-transformed hepcidin (nM) that are associated with a 1-unit change in the dependent variable, except for β values marked with “‡.”

†

BMI was included as continuous variable in the regression models.

‡

Both the dependent and independent variables were log-transformed before inclusion in the linear model. Interpretation of these β values is as follows: a 1% change in the independent variable corresponds to a β % change in the dependent variable.

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