Table 3 Results of linear regression... | American Society of Hematology

Table 3

Results of linear regression analyses for serum hepcidin concentrations (nM) adjusted for age and time of blood sampling

Variable	Men				Women
	β*	95% CI		R², %	β*	95% CI		R², %
	β*	Lower limit	Upper limit	R², %	β*	Lower limit	Upper limit	R², %
BMI, kg/m²†	0.307‡	−0.063	0.677	3.9	0.528‡	0.223	0.832	20.1
Ferritin, μg/L	0.806‡	0.770	0.843	58.7	0.853‡	0.813	0.892	62.6
Iron, μM	0.009	0.001	0.017	4.0	0.034	0.026	0.042	22.6
TIBC, μM	−0.033	−0.038	−0.028	13.5	−0.027	−0.032	−0.022	25.5
TS, %	0.013	0.009	0.017	6.1	0.025	0.020	0.030	24.8
ALT, U/L	0.070‡	−0.026	0.165	3.4	0.145‡	0.051	0.239	19.6
eGFR, mL/min/1.73 m²	−0.001	−0.004	0.001	3.9	−0.005	−0.008	−0.002	20.2
CRP
< 5 mg/L	Ref	Ref	Ref		Ref	Ref	Ref
5-20 mg/L	0.283	0.158	0.408	6.3	0.230	0.113	0.347	20.8
> 20 mg/L	0.775	0.450	1.099		0.712	0.369	1.055

Variable	Men				Women
	β*	95% CI		R², %	β*	95% CI		R², %
	β*	Lower limit	Upper limit	R², %	β*	Lower limit	Upper limit	R², %
BMI, kg/m²†	0.307‡	−0.063	0.677	3.9	0.528‡	0.223	0.832	20.1
Ferritin, μg/L	0.806‡	0.770	0.843	58.7	0.853‡	0.813	0.892	62.6
Iron, μM	0.009	0.001	0.017	4.0	0.034	0.026	0.042	22.6
TIBC, μM	−0.033	−0.038	−0.028	13.5	−0.027	−0.032	−0.022	25.5
TS, %	0.013	0.009	0.017	6.1	0.025	0.020	0.030	24.8
ALT, U/L	0.070‡	−0.026	0.165	3.4	0.145‡	0.051	0.239	19.6
eGFR, mL/min/1.73 m²	−0.001	−0.004	0.001	3.9	−0.005	−0.008	−0.002	20.2
CRP
< 5 mg/L	Ref	Ref	Ref		Ref	Ref	Ref
5-20 mg/L	0.283	0.158	0.408	6.3	0.230	0.113	0.347	20.8
> 20 mg/L	0.775	0.450	1.099		0.712	0.369	1.055

Ref indicates reference category.

The dependent variable hepcidin was log-transformed before inclusion in the models. Thus, the β values express the changes in log-transformed hepcidin (nM) that are associated with a 1-unit change in the dependent variable, except for β values marked with “‡.”

†

BMI was included as continuous variable in the regression models.

‡

Both the dependent and independent variables were log-transformed before inclusion in the linear model. Interpretation of these β values is as follows: a 1% change in the independent variable corresponds to a β % change in the dependent variable.

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