Most frequently targeted genes and gene regions at presentation and relapse in ETV6-RUNX1 ALL
| Lesion . | Gene . | Presentation . | Relapse . |
|---|---|---|---|
| Deletion | ETV6 | 15 | 14 |
| CDKN2A | 4 | 9 | |
| CDKN2B | 3 | 6 | |
| 6q16.2-3 | 4 | 7 | |
| BTG | 3 | 6 | |
| IL3RA/CSF2RA | 5 | 5 | |
| TBL1XR1 | 2 | 3 | |
| FHIT | 4 | 3 | |
| TOX | 3 | 1 | |
| RAG1/2 | 2 | 2 | |
| CD200/BTLA | 2 | 3 | |
| DMD | 1 | 3 | |
| EBF | 2 | 3 | |
| 13q14.2-3 | 1 | 3 | |
| PAX5 | 2 | 4 | |
| MKKS/ORF94 | 1 | 3 | |
| Gain | 21q22.11-22.12 | 5 | 7 |
| Xq26.2-28 | 5 | 2 | |
| 16 | 2 | 4 | |
| 12p13.33-13.31 | 2 | 2 |
| Lesion . | Gene . | Presentation . | Relapse . |
|---|---|---|---|
| Deletion | ETV6 | 15 | 14 |
| CDKN2A | 4 | 9 | |
| CDKN2B | 3 | 6 | |
| 6q16.2-3 | 4 | 7 | |
| BTG | 3 | 6 | |
| IL3RA/CSF2RA | 5 | 5 | |
| TBL1XR1 | 2 | 3 | |
| FHIT | 4 | 3 | |
| TOX | 3 | 1 | |
| RAG1/2 | 2 | 2 | |
| CD200/BTLA | 2 | 3 | |
| DMD | 1 | 3 | |
| EBF | 2 | 3 | |
| 13q14.2-3 | 1 | 3 | |
| PAX5 | 2 | 4 | |
| MKKS/ORF94 | 1 | 3 | |
| Gain | 21q22.11-22.12 | 5 | 7 |
| Xq26.2-28 | 5 | 2 | |
| 16 | 2 | 4 | |
| 12p13.33-13.31 | 2 | 2 |
These CNAs occurred in ≥ 4 samples.