Table 2.

Clinical characteristics of intestinal GVHD (I-GVHD) patients



GVHD grading

Patient
Overall
I-GVHD
Biopsy-proven I-GVHD
GCV pk after V-GCV administration
Remark
Group A, val/gan      
   1   I   I   Yes   Adequate   Diarrhea > 500 mL/day  
   2   III   II   Yes   Adequate   Diarrhea > 1000 mL/day  
   3   II   III   Yes   Severe malabsorption   Severe I-GVHD (diarrhea > 1000 mL/day) for weeks, decreasing prior to randomization; GVHD of the liver (grade II)  
Group B, gan/val      
   1   II   I   No*  Adequate   Diarrhea (≤ 10 × in total 600 mL/day); severe GVHD of the skin (grade III)  
   2   II   II   Yes   Adequate   Outpatient care  
   3
 
III
 
II
 
Yes
 
Adequate
 
Outpatient care
 


GVHD grading

Patient
Overall
I-GVHD
Biopsy-proven I-GVHD
GCV pk after V-GCV administration
Remark
Group A, val/gan      
   1   I   I   Yes   Adequate   Diarrhea > 500 mL/day  
   2   III   II   Yes   Adequate   Diarrhea > 1000 mL/day  
   3   II   III   Yes   Severe malabsorption   Severe I-GVHD (diarrhea > 1000 mL/day) for weeks, decreasing prior to randomization; GVHD of the liver (grade II)  
Group B, gan/val      
   1   II   I   No*  Adequate   Diarrhea (≤ 10 × in total 600 mL/day); severe GVHD of the skin (grade III)  
   2   II   II   Yes   Adequate   Outpatient care  
   3
 
III
 
II
 
Yes
 
Adequate
 
Outpatient care
 

val indicates valganciclovir; and gan, ganciclovir.

*

This patient had diarrhea between 500 and 1000 mL/day and a coexisting cutaneous aGVHD grade III, indicating the diarrhea to be due to intestinal GVHD

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