Clinical characteristics of intestinal GVHD (I-GVHD) patients
. | GVHD grading . | . | . | . | . | |||
---|---|---|---|---|---|---|---|---|
Patient . | Overall . | I-GVHD . | Biopsy-proven I-GVHD . | GCV pk after V-GCV administration . | Remark . | |||
Group A, val/gan | ||||||||
1 | I | I | Yes | Adequate | Diarrhea > 500 mL/day | |||
2 | III | II | Yes | Adequate | Diarrhea > 1000 mL/day | |||
3 | II | III | Yes | Severe malabsorption | Severe I-GVHD (diarrhea > 1000 mL/day) for weeks, decreasing prior to randomization; GVHD of the liver (grade II) | |||
Group B, gan/val | ||||||||
1 | II | I | No* | Adequate | Diarrhea (≤ 10 × in total 600 mL/day); severe GVHD of the skin (grade III) | |||
2 | II | II | Yes | Adequate | Outpatient care | |||
3 | III | II | Yes | Adequate | Outpatient care |
. | GVHD grading . | . | . | . | . | |||
---|---|---|---|---|---|---|---|---|
Patient . | Overall . | I-GVHD . | Biopsy-proven I-GVHD . | GCV pk after V-GCV administration . | Remark . | |||
Group A, val/gan | ||||||||
1 | I | I | Yes | Adequate | Diarrhea > 500 mL/day | |||
2 | III | II | Yes | Adequate | Diarrhea > 1000 mL/day | |||
3 | II | III | Yes | Severe malabsorption | Severe I-GVHD (diarrhea > 1000 mL/day) for weeks, decreasing prior to randomization; GVHD of the liver (grade II) | |||
Group B, gan/val | ||||||||
1 | II | I | No* | Adequate | Diarrhea (≤ 10 × in total 600 mL/day); severe GVHD of the skin (grade III) | |||
2 | II | II | Yes | Adequate | Outpatient care | |||
3 | III | II | Yes | Adequate | Outpatient care |
val indicates valganciclovir; and gan, ganciclovir.
This patient had diarrhea between 500 and 1000 mL/day and a coexisting cutaneous aGVHD grade III, indicating the diarrhea to be due to intestinal GVHD