Chronic GVHD with autoimmune manifestations in sublethally irradiated athymic BALB/cnu/nu and adult-thymectomized BALB/c recipients given DBA/2 donor cells
Host* . | Hair loss† . | Proteinuria, ++++ . | Anti-dsDNA IgG1, U/mL . | Anti-dsDNA IgG2a, U/mL . |
|---|---|---|---|---|
| BALB/cnu/nu | NA | 12/12 | 2583 ± 360 | 1650 ± 274 |
| Adult-thymectomized BALB/c | 8/8 | 8/8 | 2708 ± 412 | 1119 ± 172 |
| Sham-thymectomized BALB/c | 8/8 | 8/8 | 2099 ± 482 | 1229 ± 286 |
Host* . | Hair loss† . | Proteinuria, ++++ . | Anti-dsDNA IgG1, U/mL . | Anti-dsDNA IgG2a, U/mL . |
|---|---|---|---|---|
| BALB/cnu/nu | NA | 12/12 | 2583 ± 360 | 1650 ± 274 |
| Adult-thymectomized BALB/c | 8/8 | 8/8 | 2708 ± 412 | 1119 ± 172 |
| Sham-thymectomized BALB/c | 8/8 | 8/8 | 2099 ± 482 | 1229 ± 286 |
Recipients received 50 × 106 donor cells. Data in the last 2 columns are presented as mean ± SE.
All of the recipients developed severe proteinuria (4+) by 15 to 20 days after donor-cell injection, and serum levels of anti-dsDNA antibodies were measured on day 15 after donor-cell injection
Greater than 2 cm2 of hair loss in the neck and back by day 30 after donor-cell injection