Multivariate model of prognostic factors of EFS and OS in TT1, TT2, and TT1/TT2 combined
. | EFS, HR (95% CI)/P . | . | . | OS, HR (95% CI)/P . | . | . | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| Variable . | TT1 . | TT2 . | TT1 + TT2 . | TT1 . | TT2 . | TT1 + TT2 . | ||||
| Enrolled to TT2 | NA | NA | 0.68 (0.54-0.84)/<.001 | NA | NA | 0.79 (0.60-1.04)/.093 | ||||
| IgA | NS | 1.72 (1.19-2.47)/.004 | 1.31 (1.02-1.69)/.036 | NS | 1.84 (1.16-2.92)/.010 | 1.53 (1.14-2.06)/.004 | ||||
| B2M, natural log of mg/L | 13.0 (10.4-16.3)/.022 | NS | 12.6 (10.7-14.8)/.005 | NS | NS | NS | ||||
| Albumin, g/L | NS | 6.5 (5.3-7.9)/<.001 | 7.9 (6.8-9.3)/.003 | NS | 6.0 (4.7-7.5)/<.001 | 7.3 (6.2-8.7)/<.001 | ||||
| Cytogenetic abnormalities | 1.38 (1.02-1.86)/.034 | 1.84 (1.34-2.54)/<.001 | 1.52 (1.22-1.90)/<.001 | 1.59 (1.15-2.21)/.005 | 2.32 (1.56-3.46)/<.001 | 1.84 (1.44-2.37)/<.001 | ||||
| LDH above upper limit of normal | 1.43 (1.02-2.02)/.039 | 1.44 (1.02-2.03)/.040 | 1.37 (1.07-1.75)/.011 | 1.46 (1.02-2.10)/.041 | 1.51 (0.98-2.32)/.063 | 1.57 (1.19-2.06)/.001 | ||||
| Age, decades | NS | NS | NS | NS | 1.36 (1.10-1.69) /.005 | 1.16 (1.02-1.32)/.026 | ||||
| Hemoglobin, g/L | NS | NS | NS | 9.3 (8.6-9.9)/.023 | NS | NS | ||||
| Creatinine, | ||||||||||
| natural log of | ||||||||||
| μM/L | NS | NS | NS | 141.4 (99.0-201.6)/.009 | NS | NS | ||||
. | EFS, HR (95% CI)/P . | . | . | OS, HR (95% CI)/P . | . | . | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| Variable . | TT1 . | TT2 . | TT1 + TT2 . | TT1 . | TT2 . | TT1 + TT2 . | ||||
| Enrolled to TT2 | NA | NA | 0.68 (0.54-0.84)/<.001 | NA | NA | 0.79 (0.60-1.04)/.093 | ||||
| IgA | NS | 1.72 (1.19-2.47)/.004 | 1.31 (1.02-1.69)/.036 | NS | 1.84 (1.16-2.92)/.010 | 1.53 (1.14-2.06)/.004 | ||||
| B2M, natural log of mg/L | 13.0 (10.4-16.3)/.022 | NS | 12.6 (10.7-14.8)/.005 | NS | NS | NS | ||||
| Albumin, g/L | NS | 6.5 (5.3-7.9)/<.001 | 7.9 (6.8-9.3)/.003 | NS | 6.0 (4.7-7.5)/<.001 | 7.3 (6.2-8.7)/<.001 | ||||
| Cytogenetic abnormalities | 1.38 (1.02-1.86)/.034 | 1.84 (1.34-2.54)/<.001 | 1.52 (1.22-1.90)/<.001 | 1.59 (1.15-2.21)/.005 | 2.32 (1.56-3.46)/<.001 | 1.84 (1.44-2.37)/<.001 | ||||
| LDH above upper limit of normal | 1.43 (1.02-2.02)/.039 | 1.44 (1.02-2.03)/.040 | 1.37 (1.07-1.75)/.011 | 1.46 (1.02-2.10)/.041 | 1.51 (0.98-2.32)/.063 | 1.57 (1.19-2.06)/.001 | ||||
| Age, decades | NS | NS | NS | NS | 1.36 (1.10-1.69) /.005 | 1.16 (1.02-1.32)/.026 | ||||
| Hemoglobin, g/L | NS | NS | NS | 9.3 (8.6-9.9)/.023 | NS | NS | ||||
| Creatinine, | ||||||||||
| natural log of | ||||||||||
| μM/L | NS | NS | NS | 141.4 (99.0-201.6)/.009 | NS | NS | ||||
Continuous prognostic factors used when appropriate.
NA indicates not applicable; NS, not significant.