Genes that are preferentially up- or down-regulated in DCs
Gene names (HUGO symbols) . | Accession no. . | Monocytes . | Macrophages . | imDCs . | mDCs . |
|---|---|---|---|---|---|
| TGF-β induced, 68 kDa (TGFBI) | BC004972 | -0.46 | 0.09 | 1.72 | -1.34 |
| Coagulation factor XIII A1 polypeptide (F13A1) | AF418272 | -0.82 | -0.55 | 2.20 | -0.83 |
| M-CSFR (CSFIR) | X03663 | 0.10 | 0.42 | 1.08 | -1.59 |
| Laminin β3 (LAMB3) | D37766 | -1.52 | 0.19 | 1.87 | -0.54 |
| CD1A antigen (CD1A) | M28825 | -1.10 | -1.17 | 1.56 | 0.71 |
| CCR1 (CCR1) | D10925 | -0.06 | 0.67 | 0.52 | -1.12 |
| Rho GDI β (ARHGDIB) | L20688 | -0.45 | -0.20 | 1.06 | -0.41 |
| p56Dok2(DOK2) | AF034970 | -0.40 | -0.54 | 1.20 | -0.26 |
| ATP-binding cassette/MRP3 (ABCC3) | Y17151 | -1.00 | -0.45 | 1.26 | 0.18 |
| Formin-like protein (FMNL1) | NM_005892 | -0.42 | -0.25 | 0.79 | -0.12 |
| Mannose receptor (MRC1) | X55635 | -1.08 | -0.28 | 1.11 | 0.25 |
| AKAP12 A kinase anchor protein 12 (AKAP12) | AB003476 | -0.84 | -0.08 | 0.85 | 0.08 |
| Chromosome 5 clone (CTC-224D3) | AC008385 | -0.89 | -0.33 | 0.98 | 0.25 |
| Ribosomal protein S16 (RPS16) | NM001020 | -1.24 | -0.03 | 1.13 | 0.14 |
| Mitochondrial gene (ND41) | AF382006 | -0.43 | -0.70 | 1.00 | 0.13 |
| Monoglyceride lipase (MGLL) | AK025983 | -1.35 | 0.14 | -0.90 | 2.11 |
| Activating transcription factor 3 (ATF3) | N39944 | -0.29 | 0.28 | -1.29 | 1.30 |
| Diubiquitin (UBD) | AW270961 | -1.35 | -0.77 | -0.17 | 2.30 |
| Inhibitor of apoptosis protein-1 (MIHC) | AF070674 | -0.33 | -0.97 | -0.55 | 1.85 |
| Peripheral myelin protein 2 (PMP22) | AA128311 | -0.54 | 0.27 | -0.92 | 1.18 |
| RGS1 (RGS1) | S59049 | -0.10 | -1.17* | -0.70* | 1.34 |
| Calmodulin 2 (CALM2) | BF671011 | -1.63 | -0.58 | 0.21 | 2.00 |
| NA | NA | -0.53 | -0.53 | -0.34 | 1.40 |
| Transgelin 2 (TAGLN2) | BE407460 | -0.40 | -0.26 | -0.46 | 1.26 |
| PA28 α (PSME2) | AA310524 | -0.96 | 0.22 | -0.46 | 1.20 |
| CCR7 (CCR7) | L08176 | 0.42 | -1.54 | -0.18 | 1.30 |
| Monoamine oxidase (MAOA) | M69226 | -0.99 | -0.79 | 0.20 | 1.58 |
| UV radiation resistance-associated gene (UVRAG) | AB012958 | -0.95 | -0.70 | 0.28 | 1.37 |
| NA | NA | -0.93 | -0.33 | 0.09 | 1.17 |
| Neuroepithelial cell transforming gene (NET1) | BF197249 | -0.99 | -0.64* | 0.26 | 1.16 |
| Tubulin β5 (TUBB) | BC019924 | -1.31 | -0.08 | 0.35 | 1.04 |
| di-N-acetyl-chitobiase (CTBS) | AW853098 | -0.98 | -0.43 | 0.34 | 1.06 |
| TARC (CCL17) | NM_002987 | -1.18 | -1.52* | 1.03 | 1.17 |
| Kunitz serine protease inhibitor (SP1NT2) | AB006534 | -1.51 | -0.81 | 0.92 | 1.40 |
| Cyclin-dependent kinase inhibitor 1A (p21) (CDKN1A) | U09579 | -1.20 | -0.51 | 0.45 | 1.26 |
| Fatty acid-binding protein 4 (FABP4) | AW631118 | -0.54 | -1.00 | 1.18 | 0.54 |
| Mitochondrial isoleucine tRNA synthetase (FLJ10326) | AA262600 | -0.90 | -0.41 | 1.18 | 0.62 |
| Cdc23 (CDC23) | BC017713 | -0.88 | -0.61 | 0.69 | 0.79 |
| YEATS domain containing 2 (YEATS2) | AK022903 | 0.10 | -1.32 | 1.01 | 0.46 |
| CD4 antigen (CD4) | U47924 | -1.09 | -0.29 | 0.66 | 0.72 |
| Interferon gamma receptor 2 (IGNGR2) | U05875 | -0.98 | -0.40 | 0.43 | 0.95 |
| Synaptogyrin 2 (SYNGR2) | AA465253 | -0.87 | -0.51 | 0.56 | 0.82 |
| KIAA0586 gene product (KIAA0586) | AB0I1158 | -0.97 | -0.40 | 0.47 | 0.91 |
| WASP-interacting protein (WASPIP) | NM_003387 | -0.65 | -0.45 | 0.63 | 0.68 |
| ARP2/3 subunit 4 (ARPC4) | R56649 | -0.73 | -0.29 | 0.67 | 0.35 |
| M-ficolin (FCN1) | NM_002003 | 1.11 | 1.29 | -1.48 | -1.38 |
| Solute carrier family 21 (SLCO1A2) | NM_005075 | 0.87 | 1.51 | -1.38 | -1.50 |
| Kreisler maf-related leucine zipper homolog (MAFB) | NM_005461 | 1.65 | 1.06 | 0.08 | -2.09 |
| CD16a (FCGR3A) | X52645 | 0.64 | 2.02 | -1.27 | -1.39 |
| ILT5 (LILRB3) | AF009644 | 0.37 | 1.49 | -0.62 | -1.23 |
| Complement C3 (C3) | NM_000064 | 0.68 | 1.43 | -1.32 | -0.79 |
| 1-8U (IFITM3) | BE906728 | 1.34 | 0.75 | -0.61 | -1.48 |
| ILT2 (LAIR1) | NM_002287 | 0.20 | 1.41 | -0.76 | -1.12 |
| G-CSFR1 (CSF3R) | M59818 | 0.44 | 0.99 | -1.03 | -0.74 |
| S100 calcium-binding protein A9 (S100A9) | X06233 | 0.53 | 0.82 | -0.72 | -0.95 |
Gene names (HUGO symbols) . | Accession no. . | Monocytes . | Macrophages . | imDCs . | mDCs . |
|---|---|---|---|---|---|
| TGF-β induced, 68 kDa (TGFBI) | BC004972 | -0.46 | 0.09 | 1.72 | -1.34 |
| Coagulation factor XIII A1 polypeptide (F13A1) | AF418272 | -0.82 | -0.55 | 2.20 | -0.83 |
| M-CSFR (CSFIR) | X03663 | 0.10 | 0.42 | 1.08 | -1.59 |
| Laminin β3 (LAMB3) | D37766 | -1.52 | 0.19 | 1.87 | -0.54 |
| CD1A antigen (CD1A) | M28825 | -1.10 | -1.17 | 1.56 | 0.71 |
| CCR1 (CCR1) | D10925 | -0.06 | 0.67 | 0.52 | -1.12 |
| Rho GDI β (ARHGDIB) | L20688 | -0.45 | -0.20 | 1.06 | -0.41 |
| p56Dok2(DOK2) | AF034970 | -0.40 | -0.54 | 1.20 | -0.26 |
| ATP-binding cassette/MRP3 (ABCC3) | Y17151 | -1.00 | -0.45 | 1.26 | 0.18 |
| Formin-like protein (FMNL1) | NM_005892 | -0.42 | -0.25 | 0.79 | -0.12 |
| Mannose receptor (MRC1) | X55635 | -1.08 | -0.28 | 1.11 | 0.25 |
| AKAP12 A kinase anchor protein 12 (AKAP12) | AB003476 | -0.84 | -0.08 | 0.85 | 0.08 |
| Chromosome 5 clone (CTC-224D3) | AC008385 | -0.89 | -0.33 | 0.98 | 0.25 |
| Ribosomal protein S16 (RPS16) | NM001020 | -1.24 | -0.03 | 1.13 | 0.14 |
| Mitochondrial gene (ND41) | AF382006 | -0.43 | -0.70 | 1.00 | 0.13 |
| Monoglyceride lipase (MGLL) | AK025983 | -1.35 | 0.14 | -0.90 | 2.11 |
| Activating transcription factor 3 (ATF3) | N39944 | -0.29 | 0.28 | -1.29 | 1.30 |
| Diubiquitin (UBD) | AW270961 | -1.35 | -0.77 | -0.17 | 2.30 |
| Inhibitor of apoptosis protein-1 (MIHC) | AF070674 | -0.33 | -0.97 | -0.55 | 1.85 |
| Peripheral myelin protein 2 (PMP22) | AA128311 | -0.54 | 0.27 | -0.92 | 1.18 |
| RGS1 (RGS1) | S59049 | -0.10 | -1.17* | -0.70* | 1.34 |
| Calmodulin 2 (CALM2) | BF671011 | -1.63 | -0.58 | 0.21 | 2.00 |
| NA | NA | -0.53 | -0.53 | -0.34 | 1.40 |
| Transgelin 2 (TAGLN2) | BE407460 | -0.40 | -0.26 | -0.46 | 1.26 |
| PA28 α (PSME2) | AA310524 | -0.96 | 0.22 | -0.46 | 1.20 |
| CCR7 (CCR7) | L08176 | 0.42 | -1.54 | -0.18 | 1.30 |
| Monoamine oxidase (MAOA) | M69226 | -0.99 | -0.79 | 0.20 | 1.58 |
| UV radiation resistance-associated gene (UVRAG) | AB012958 | -0.95 | -0.70 | 0.28 | 1.37 |
| NA | NA | -0.93 | -0.33 | 0.09 | 1.17 |
| Neuroepithelial cell transforming gene (NET1) | BF197249 | -0.99 | -0.64* | 0.26 | 1.16 |
| Tubulin β5 (TUBB) | BC019924 | -1.31 | -0.08 | 0.35 | 1.04 |
| di-N-acetyl-chitobiase (CTBS) | AW853098 | -0.98 | -0.43 | 0.34 | 1.06 |
| TARC (CCL17) | NM_002987 | -1.18 | -1.52* | 1.03 | 1.17 |
| Kunitz serine protease inhibitor (SP1NT2) | AB006534 | -1.51 | -0.81 | 0.92 | 1.40 |
| Cyclin-dependent kinase inhibitor 1A (p21) (CDKN1A) | U09579 | -1.20 | -0.51 | 0.45 | 1.26 |
| Fatty acid-binding protein 4 (FABP4) | AW631118 | -0.54 | -1.00 | 1.18 | 0.54 |
| Mitochondrial isoleucine tRNA synthetase (FLJ10326) | AA262600 | -0.90 | -0.41 | 1.18 | 0.62 |
| Cdc23 (CDC23) | BC017713 | -0.88 | -0.61 | 0.69 | 0.79 |
| YEATS domain containing 2 (YEATS2) | AK022903 | 0.10 | -1.32 | 1.01 | 0.46 |
| CD4 antigen (CD4) | U47924 | -1.09 | -0.29 | 0.66 | 0.72 |
| Interferon gamma receptor 2 (IGNGR2) | U05875 | -0.98 | -0.40 | 0.43 | 0.95 |
| Synaptogyrin 2 (SYNGR2) | AA465253 | -0.87 | -0.51 | 0.56 | 0.82 |
| KIAA0586 gene product (KIAA0586) | AB0I1158 | -0.97 | -0.40 | 0.47 | 0.91 |
| WASP-interacting protein (WASPIP) | NM_003387 | -0.65 | -0.45 | 0.63 | 0.68 |
| ARP2/3 subunit 4 (ARPC4) | R56649 | -0.73 | -0.29 | 0.67 | 0.35 |
| M-ficolin (FCN1) | NM_002003 | 1.11 | 1.29 | -1.48 | -1.38 |
| Solute carrier family 21 (SLCO1A2) | NM_005075 | 0.87 | 1.51 | -1.38 | -1.50 |
| Kreisler maf-related leucine zipper homolog (MAFB) | NM_005461 | 1.65 | 1.06 | 0.08 | -2.09 |
| CD16a (FCGR3A) | X52645 | 0.64 | 2.02 | -1.27 | -1.39 |
| ILT5 (LILRB3) | AF009644 | 0.37 | 1.49 | -0.62 | -1.23 |
| Complement C3 (C3) | NM_000064 | 0.68 | 1.43 | -1.32 | -0.79 |
| 1-8U (IFITM3) | BE906728 | 1.34 | 0.75 | -0.61 | -1.48 |
| ILT2 (LAIR1) | NM_002287 | 0.20 | 1.41 | -0.76 | -1.12 |
| G-CSFR1 (CSF3R) | M59818 | 0.44 | 0.99 | -1.03 | -0.74 |
| S100 calcium-binding protein A9 (S100A9) | X06233 | 0.53 | 0.82 | -0.72 | -0.95 |
Fifty-five genes are listed according to their up- or down-regulation in imDCs or mDCs, or both. The identities of these genes are identified by HUGO symbols (in parentheses and italics) and accession numbers. The expression values represent the average of 3 experiments except for those few values labeled with an asterisk, which denotes an average value of 2 experiments. These 55 genes were listed as 4 groups according to expression values in imDCs or mDCs (or both) identified with underlining.
CCR indicates CC chemokine receptor; p56Dok2, docking protein; RGS, regulator of G-protein signaling; NA, not annotated; PA28α, proteasome activator subunit 1; TARC, thymus and activation-regulated chemokine; ILT, immunoglobulin-like transcript; and I-8U, interferon-induced transmembrane protein 3.