Univariate analysis for the probability of TFS
Variable . | No. patients . | No. events (%) . | Fisher exact test P . | Kaplan-Meier probability (95% CI) . | P . |
|---|---|---|---|---|---|
| Sex | .13 | .14 | |||
| Female | 31 | 6 (19) | 79 (64-94) | ||
| Male | 41 | 16 (39) | 61 (46-77) | ||
| Sex mismatch in GvH direction, donor→recipient | .40 | .36 | |||
| Female→Male | 19 | 7 (37) | 62 (39-84) | ||
| Other combinations | 53 | 14 (26) | 71 (58-84) | ||
| Sex mismatch in HvG direction, donor→recipient | NS | NS | |||
| Male→female | 18 | 5 (28) | 69 (47-92) | ||
| Other combinations | 54 | 16 (30) | 69 (56-81) | ||
| Patient age at HSCT | .45 | .39 | |||
| Younger than 15 y | 36 | 9 (25) | 73 (57-88) | ||
| 15 y or older | 36 | 12 (33) | 65 (49-81) | ||
| Donor age | .31 | .40 | |||
| Younger than 35 y | 31 | 7 (23) | 77 (62-92) | ||
| 35 y or older | 41 | 14 (34) | 63 (47-79) | ||
| Pesaro classification | .12* | .16 | |||
| Class 1 | 21 | 4 (19) | 77 (56-97) | ||
| Class 2 | 20 | 4 (20) | 80 (62-98) | ||
| Class 3 | 31 | 13 (42) | 57 (39-75) | ||
| HCMV serology, donor→recipient | .23* | .31 | |||
| Negative→negative | 7 | 2 (29) | 71 (38-100) | ||
| Negative→positive | 16 | 6 (38) | 59 (34-85) | ||
| Positive→negative | 14 | 1 (7) | 93 (79-100) | ||
| Positive→positive | 35 | 12 (34) | 64 (47-80) | ||
| HCMV serology combination, donor→recipient | NS | NS | |||
| Negative→negative | 7 | 2 (29) | 71 (38-100) | ||
| Others | 65 | 19 (29) | 68 (56-80) | ||
| Conditioning regimen | NS* | NS | |||
| BU + CY | 18 | 6 (33) | 66 (44-88) | ||
| BU + TT + CY | 36 | 11 (31) | 69 (53-84) | ||
| BU + TT + FLU | 18 | 4 (22) | 70 (45-95) | ||
| Use of ATG | NS | .45 | |||
| No | 54 | 17 (31) | 68 (55-80) | ||
| Yes | 18 | 4 (22) | 70 (45-95) | ||
| Cell dose infused, × 108/kg | .30 | .18 | |||
| Less than 5 | 44 | 15 (34) | 64 (50-79) | ||
| 5 or greater | 28 | 6 (21) | 75 (58-93) | ||
| HLA-DPB1 mismatch | .25* | .18 | |||
| Matched + permissive | 45 | 10 (22) | 76 (63-89) | ||
| Nonpermissive mismatch in GvH direction | 10 | 4 (40) | 53 (19-88) | ||
| Nonpermissive mismatch in HvG direction | 17 | 7 (41) | 57 (33-81) |
Variable . | No. patients . | No. events (%) . | Fisher exact test P . | Kaplan-Meier probability (95% CI) . | P . |
|---|---|---|---|---|---|
| Sex | .13 | .14 | |||
| Female | 31 | 6 (19) | 79 (64-94) | ||
| Male | 41 | 16 (39) | 61 (46-77) | ||
| Sex mismatch in GvH direction, donor→recipient | .40 | .36 | |||
| Female→Male | 19 | 7 (37) | 62 (39-84) | ||
| Other combinations | 53 | 14 (26) | 71 (58-84) | ||
| Sex mismatch in HvG direction, donor→recipient | NS | NS | |||
| Male→female | 18 | 5 (28) | 69 (47-92) | ||
| Other combinations | 54 | 16 (30) | 69 (56-81) | ||
| Patient age at HSCT | .45 | .39 | |||
| Younger than 15 y | 36 | 9 (25) | 73 (57-88) | ||
| 15 y or older | 36 | 12 (33) | 65 (49-81) | ||
| Donor age | .31 | .40 | |||
| Younger than 35 y | 31 | 7 (23) | 77 (62-92) | ||
| 35 y or older | 41 | 14 (34) | 63 (47-79) | ||
| Pesaro classification | .12* | .16 | |||
| Class 1 | 21 | 4 (19) | 77 (56-97) | ||
| Class 2 | 20 | 4 (20) | 80 (62-98) | ||
| Class 3 | 31 | 13 (42) | 57 (39-75) | ||
| HCMV serology, donor→recipient | .23* | .31 | |||
| Negative→negative | 7 | 2 (29) | 71 (38-100) | ||
| Negative→positive | 16 | 6 (38) | 59 (34-85) | ||
| Positive→negative | 14 | 1 (7) | 93 (79-100) | ||
| Positive→positive | 35 | 12 (34) | 64 (47-80) | ||
| HCMV serology combination, donor→recipient | NS | NS | |||
| Negative→negative | 7 | 2 (29) | 71 (38-100) | ||
| Others | 65 | 19 (29) | 68 (56-80) | ||
| Conditioning regimen | NS* | NS | |||
| BU + CY | 18 | 6 (33) | 66 (44-88) | ||
| BU + TT + CY | 36 | 11 (31) | 69 (53-84) | ||
| BU + TT + FLU | 18 | 4 (22) | 70 (45-95) | ||
| Use of ATG | NS | .45 | |||
| No | 54 | 17 (31) | 68 (55-80) | ||
| Yes | 18 | 4 (22) | 70 (45-95) | ||
| Cell dose infused, × 108/kg | .30 | .18 | |||
| Less than 5 | 44 | 15 (34) | 64 (50-79) | ||
| 5 or greater | 28 | 6 (21) | 75 (58-93) | ||
| HLA-DPB1 mismatch | .25* | .18 | |||
| Matched + permissive | 45 | 10 (22) | 76 (63-89) | ||
| Nonpermissive mismatch in GvH direction | 10 | 4 (40) | 53 (19-88) | ||
| Nonpermissive mismatch in HvG direction | 17 | 7 (41) | 57 (33-81) |
Chi-squared P