Table 1. Clinical data for patients with... | American Society of Hematology

Table 1.

Clinical data for patients with β-thalassemia and their UDs

	HLA-DPB1^*
	Matched and permissive	Nonpermissive
	Matched and permissive		HvG direction	GvH direction
No. of patients	45	17	10
Sex of donor/recipient, no. cases
Female/male	11	3	3
Other combinations	34	14	7
Median age, y (range)
Donor	32 (21-44)	33 (19-48)	36 (20-52)
Patient	15 (6-24)	15 (1.5-37)	14 (1.5-26)
Class†, no.
1	14	5	2
2	12	6	2
3	19	6	6
Donor/recipient HCMV serology, no. cases
Negative/negative	2	4	1
Other combinations	43	13	9
Median cell dose, × 10⁸/kg (range)	3.8 (2-8.3)	4.8 (0.2-15)	4.5 (0.3-12)
Conditioning, no.
BU-CY	11	5	2
BU-TT-CY	21	9	6
BU-TT-FLU-ATG	13	3	2
Rejection, no.	2	4	1
aGvHD II–IV‡, no.	14	8	4
OS, no.	37	13	7
TFS, no.	35	10	6

	HLA-DPB1^*
	Matched and permissive	Nonpermissive
	Matched and permissive		HvG direction	GvH direction
No. of patients	45	17	10
Sex of donor/recipient, no. cases
Female/male	11	3	3
Other combinations	34	14	7
Median age, y (range)
Donor	32 (21-44)	33 (19-48)	36 (20-52)
Patient	15 (6-24)	15 (1.5-37)	14 (1.5-26)
Class†, no.
1	14	5	2
2	12	6	2
3	19	6	6
Donor/recipient HCMV serology, no. cases
Negative/negative	2	4	1
Other combinations	43	13	9
Median cell dose, × 10⁸/kg (range)	3.8 (2-8.3)	4.8 (0.2-15)	4.5 (0.3-12)
Conditioning, no.
BU-CY	11	5	2
BU-TT-CY	21	9	6
BU-TT-FLU-ATG	13	3	2
Rejection, no.	2	4	1
aGvHD II–IV‡, no.	14	8	4
OS, no.	37	13	7
TFS, no.	35	10	6

Classification of HLA-DPB1 alleles was performed according to the algorithm described before¹²

Class according to Pesaro classification⁸

Seventy-one of 72 pairs were evaluable for aGvHD (45 matched or permissive, 9 nonpermissive in GvH and 17 nonpermissive in HvG direction)