Guidelines for administration of hydroxyurea during induction
WBC count, × 109/L . | Adult patients . | Pediatric patients . |
|---|---|---|
| 5 to 10 | 500 mg once daily | 15 mg/kg once daily |
| 10 to 15 | 500 mg twice daily | 15 mg/kg twice daily |
| 15 to 20 | 500 mg thrice daily | 15 mg/kg thrice daily |
| 20 to 50 | 500 mg 4 times a day | 15 mg/kg 4 times a day |
| More than 50 | 1.0 g 4 times a day | 30 mg/kg 4 times a day |
WBC count, × 109/L . | Adult patients . | Pediatric patients . |
|---|---|---|
| 5 to 10 | 500 mg once daily | 15 mg/kg once daily |
| 10 to 15 | 500 mg twice daily | 15 mg/kg twice daily |
| 15 to 20 | 500 mg thrice daily | 15 mg/kg thrice daily |
| 20 to 50 | 500 mg 4 times a day | 15 mg/kg 4 times a day |
| More than 50 | 1.0 g 4 times a day | 30 mg/kg 4 times a day |
For adult and pediatric patients with a WBC count less than 5 × 109/L, no hydroxyurea was administered.