Red cell survival data
. | Subject . | . | . | . | . | . | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
. | 1 . | 2 . | 3 . | 4 . | 5 . | 6 . | |||||
| G1 antibody-coated cells | |||||||||||
| Label | 99mTc | 51Cr | 99mTc | 51Cr | 99mTc | NA | |||||
| Whole blood count at 5-minute time point (percent injected dose) | 84 | 71 | 81 | 75 | 84 | NA | |||||
| Whole blood count at 60-minute time point (percent 5-minute sample) | 22 | 30 | 26 | 22 | 12 | NA | |||||
| Maximum plasma value (percent injected dose) | — | 6.1 | — | 4.5 | — | NA | |||||
| Rate constant for clearance of all cells (min-1)* | 0.030 | 0.027 | 0.026 | 0.031 | 0.046 | NA | |||||
| G1Δnab antibody-coated cells | |||||||||||
| Label | 51Cr | 99mTc | 51Cr | 99mTc | 51Cr | 99mTc | |||||
| Whole blood count at 5-minute time point (percent injected dose) | 79 | 90 | 82 | 84 | 77 | 82 | |||||
| Whole blood count at 60-minute time point (percent 5-minute sample) | 47 | 52 | 61 | 37 | 22 | 48 | |||||
| Maximum plasma value (percent injected dose) | 1.6 | — | 0.8 | — | 0.5 | — | |||||
| Rate constant for clearance of all cells (min-1)* | 0.014 | 0.012 | 0.009 | 0.019 | 0.026 | 0.013 | |||||
| Rate constant for clearance to asymptote only, (min-1)† | 0.024 | 0.020 | 0.027 | 0.020 | 0.030 | 0.022 | |||||
| Plateau/asymptote (percent injected dose)† | 21 | 19 | 40 | 6 | 6 | 18 | |||||
| Rebound | |||||||||||
| Time of highest measured rebound (hours) | 23 | 20 | 21 | 21 | 144‡ | ND | |||||
| Whole blood count at rebound (percent injected dose) | 39 | 23 | 67 | 12 | 18 | ND | |||||
. | Subject . | . | . | . | . | . | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
. | 1 . | 2 . | 3 . | 4 . | 5 . | 6 . | |||||
| G1 antibody-coated cells | |||||||||||
| Label | 99mTc | 51Cr | 99mTc | 51Cr | 99mTc | NA | |||||
| Whole blood count at 5-minute time point (percent injected dose) | 84 | 71 | 81 | 75 | 84 | NA | |||||
| Whole blood count at 60-minute time point (percent 5-minute sample) | 22 | 30 | 26 | 22 | 12 | NA | |||||
| Maximum plasma value (percent injected dose) | — | 6.1 | — | 4.5 | — | NA | |||||
| Rate constant for clearance of all cells (min-1)* | 0.030 | 0.027 | 0.026 | 0.031 | 0.046 | NA | |||||
| G1Δnab antibody-coated cells | |||||||||||
| Label | 51Cr | 99mTc | 51Cr | 99mTc | 51Cr | 99mTc | |||||
| Whole blood count at 5-minute time point (percent injected dose) | 79 | 90 | 82 | 84 | 77 | 82 | |||||
| Whole blood count at 60-minute time point (percent 5-minute sample) | 47 | 52 | 61 | 37 | 22 | 48 | |||||
| Maximum plasma value (percent injected dose) | 1.6 | — | 0.8 | — | 0.5 | — | |||||
| Rate constant for clearance of all cells (min-1)* | 0.014 | 0.012 | 0.009 | 0.019 | 0.026 | 0.013 | |||||
| Rate constant for clearance to asymptote only, (min-1)† | 0.024 | 0.020 | 0.027 | 0.020 | 0.030 | 0.022 | |||||
| Plateau/asymptote (percent injected dose)† | 21 | 19 | 40 | 6 | 6 | 18 | |||||
| Rebound | |||||||||||
| Time of highest measured rebound (hours) | 23 | 20 | 21 | 21 | 144‡ | ND | |||||
| Whole blood count at rebound (percent injected dose) | 39 | 23 | 67 | 12 | 18 | ND | |||||
ND indicates not determined; NA, not applicable (subject 6 did not receive G1-coated cells); and —, plasma values given for 51Cr only due to the high rate of elution of 99mTc from cells.
Rate constant, b, obtained by fitting cell clearance data for the 5- to 60-minute period to the function C(t) = B exp(—bt).
Rate constant, b, and plateau, A, obtained by fitting cell clearance data for the 0- to 300-minute period to the function C(t) = A + B exp(—bt).
For subject 5, no samples were taken one day after injection.