VDJ intraclonal heterogeneity in IgM MGUS
Patient ID . | VH . | JH . | % VDJ mutation* . | VDJ intraclonal diversity . | No. of diversified clones/no. of total clones sequenced . | Switch μ mutation . |
|---|---|---|---|---|---|---|
| MGUS1 | 3 | 4 | 4.1 | + | 5/21 | + |
| MMGUS2 | 3 | 4 | 9.0 | + | 3/7 | + |
| MMGUS4 | 3 | 4 | 7.5 | + | 3/8 | + |
| MMGUS5 | 3 | 4 | 6.1 | + | 6/11 | ND |
| MMGUS3 | 6 | 4 | 5.4 | – | 0/8 | – |
Patient ID . | VH . | JH . | % VDJ mutation* . | VDJ intraclonal diversity . | No. of diversified clones/no. of total clones sequenced . | Switch μ mutation . |
|---|---|---|---|---|---|---|
| MGUS1 | 3 | 4 | 4.1 | + | 5/21 | + |
| MMGUS2 | 3 | 4 | 9.0 | + | 3/7 | + |
| MMGUS4 | 3 | 4 | 7.5 | + | 3/8 | + |
| MMGUS5 | 3 | 4 | 6.1 | + | 6/11 | ND |
| MMGUS3 | 6 | 4 | 5.4 | – | 0/8 | – |
ND indicates not determined.
Mutation rate is calculated based on the consensus VDJ sequences