Associations between Th1/Th2 cytokine polymorphisms, BMI, and risk of NHL
| SNPs . | Overall . | B-cell lymphoma . | T-cell lymphoma . | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BMI < 25, kg/m2 . | BMI ≥ 25, kg/m2 . | BMI < 25, kg/m2 . | BMI ≥ 25, kg/m2 . | BMI < 25, kg/m2 . | BMI ≥ 25, kg/m2 . | |||||||||
| Controls . | Cases . | OR (95% CI) . | Controls . | Cases . | OR (95% CI) . | Cases . | OR (95% CI) . | Cases . | OR (95% CI) . | Cases . | OR (95% CI) . | Cases . | OR (95% CI) . | |
| IFNGR2_01 (rs9808753) | ||||||||||||||
| AA | 247 | 180 | 1.0 | 189 | 202 | 1.5 (1.1-1.9) | 146 | 1.0 | 161 | 1.4 (1.1-1.9) | 8 | 1.0 | 18 | 2.9 (1.2-7.0) |
| AG or GG | 62 | 54 | 1.0 | 69 | 49 | 0.9 (0.5-1.5) | 41 | 1.0 | 41 | 1.0 (0.5-1.7) | 5 | 1.0 | 5 | 0.8 (0.2-3.1) |
| Pforinteraction | .034 | .108 | .057 | |||||||||||
| IL5_02 (rs2069812) | ||||||||||||||
| CC | 145 | 114 | 1.0 | 128 | 105 | 1.0 (0.7-1.4) | 87 | 1.0 | 85 | 1.0 (0.7-1.5) | 9 | 1.0 | 9 | 1.0 (0.4-2.6) |
| CT or TT | 160 | 116 | 1.0 | 129 | 145 | 1.7 (1.2-2.4) | 96 | 1.0 | 114 | 1.6 (1.1-2.3) | 3 | 1.0 | 14 | 5.9 (1.6-21.5) |
| Pforinteraction | .081 | .236 | .034 | |||||||||||
| IL7R_01 (rs1494555) | ||||||||||||||
| AA | 141 | 89 | 1.0 | 104 | 116 | 1.9 (1.3-2.8) | 73 | 1.0 | 98 | 1.9 (1.3-2.9) | 2 | 1.0 | 7 | 5.8 (1.1-31.6) |
| AG or GG | 153 | 127 | 1.0 | 134 | 120 | 1.1 (0.8-1.6) | 103 | 1.0 | 89 | 1.0 (0.7-1.4) | 8 | 1.0 | 15 | 2.2 (0.9-5.5) |
| Pforinteraction | .016 | .016 | .120 | |||||||||||
| TNF_07 (rs1799724) | ||||||||||||||
| CC | 243 | 168 | 1.0 | 188 | 195 | 1.5 (1.1-2.0) | 134 | 1.0 | 161 | 1.6 (1.2-2.1) | 8 | 1.0 | 18 | 2.9 (1.2-6.8) |
| CT or TT | 59 | 57 | 1.0 | 66 | 57 | 0.9 (0.5-1.6) | 46 | 1.0 | 41 | 0.8 (0.5-1.4) | 3 | 1.0 | 4 | 1.6 (0.3-8.1) |
| Pforinteraction | .056 | .031 | .147 | |||||||||||
| SNPs . | Overall . | B-cell lymphoma . | T-cell lymphoma . | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BMI < 25, kg/m2 . | BMI ≥ 25, kg/m2 . | BMI < 25, kg/m2 . | BMI ≥ 25, kg/m2 . | BMI < 25, kg/m2 . | BMI ≥ 25, kg/m2 . | |||||||||
| Controls . | Cases . | OR (95% CI) . | Controls . | Cases . | OR (95% CI) . | Cases . | OR (95% CI) . | Cases . | OR (95% CI) . | Cases . | OR (95% CI) . | Cases . | OR (95% CI) . | |
| IFNGR2_01 (rs9808753) | ||||||||||||||
| AA | 247 | 180 | 1.0 | 189 | 202 | 1.5 (1.1-1.9) | 146 | 1.0 | 161 | 1.4 (1.1-1.9) | 8 | 1.0 | 18 | 2.9 (1.2-7.0) |
| AG or GG | 62 | 54 | 1.0 | 69 | 49 | 0.9 (0.5-1.5) | 41 | 1.0 | 41 | 1.0 (0.5-1.7) | 5 | 1.0 | 5 | 0.8 (0.2-3.1) |
| Pforinteraction | .034 | .108 | .057 | |||||||||||
| IL5_02 (rs2069812) | ||||||||||||||
| CC | 145 | 114 | 1.0 | 128 | 105 | 1.0 (0.7-1.4) | 87 | 1.0 | 85 | 1.0 (0.7-1.5) | 9 | 1.0 | 9 | 1.0 (0.4-2.6) |
| CT or TT | 160 | 116 | 1.0 | 129 | 145 | 1.7 (1.2-2.4) | 96 | 1.0 | 114 | 1.6 (1.1-2.3) | 3 | 1.0 | 14 | 5.9 (1.6-21.5) |
| Pforinteraction | .081 | .236 | .034 | |||||||||||
| IL7R_01 (rs1494555) | ||||||||||||||
| AA | 141 | 89 | 1.0 | 104 | 116 | 1.9 (1.3-2.8) | 73 | 1.0 | 98 | 1.9 (1.3-2.9) | 2 | 1.0 | 7 | 5.8 (1.1-31.6) |
| AG or GG | 153 | 127 | 1.0 | 134 | 120 | 1.1 (0.8-1.6) | 103 | 1.0 | 89 | 1.0 (0.7-1.4) | 8 | 1.0 | 15 | 2.2 (0.9-5.5) |
| Pforinteraction | .016 | .016 | .120 | |||||||||||
| TNF_07 (rs1799724) | ||||||||||||||
| CC | 243 | 168 | 1.0 | 188 | 195 | 1.5 (1.1-2.0) | 134 | 1.0 | 161 | 1.6 (1.2-2.1) | 8 | 1.0 | 18 | 2.9 (1.2-6.8) |
| CT or TT | 59 | 57 | 1.0 | 66 | 57 | 0.9 (0.5-1.6) | 46 | 1.0 | 41 | 0.8 (0.5-1.4) | 3 | 1.0 | 4 | 1.6 (0.3-8.1) |
| Pforinteraction | .056 | .031 | .147 | |||||||||||
ORs were adjusted for age, race, and total energy intakes.