Table 1 Summary of NOX family proteins,... | American Society of Hematology

Table 1

Summary of NOX family proteins, human tissue distribution, and known regulatory factors

Enzyme	Tissue distribution*	Known regulatory factors
NOX1	Colon epithelial cells, vascular smooth muscle	Primarily NOXO1, NOXA1, and p22^Phox
NOX2 (gp91^Phox)	Phagocytes	p22^Phox, p47^Phox, p67^Phox, p40^Phox, and Rac
NOX3	Inner ear	p22^Phox, other subunits may contribute
NOX4	Kidney, vascular endothelial cells, vascular smooth muscle	p22^Phox
NOX5	Spleen, testis, vascular smooth muscle	Calcium
DUOX1	Thyroid, lung, prostate, testis, salivary glands, pancreas	Calcium, DUOXA1
DUOX2	Thyroid, intestinal tract	Calcium, DUOXA2

Enzyme	Tissue distribution*	Known regulatory factors
NOX1	Colon epithelial cells, vascular smooth muscle	Primarily NOXO1, NOXA1, and p22^Phox
NOX2 (gp91^Phox)	Phagocytes	p22^Phox, p47^Phox, p67^Phox, p40^Phox, and Rac
NOX3	Inner ear	p22^Phox, other subunits may contribute
NOX4	Kidney, vascular endothelial cells, vascular smooth muscle	p22^Phox
NOX5	Spleen, testis, vascular smooth muscle	Calcium
DUOX1	Thyroid, lung, prostate, testis, salivary glands, pancreas	Calcium, DUOXA1
DUOX2	Thyroid, intestinal tract	Calcium, DUOXA2

NOX1, 2, and 4 are also expressed in human CD34⁺ hematopoietic progenitor cells.