Previous reports of hematopoietic stem cell transplant for patients with chronic active EBV
| Reference . | EBV+ cells . | Age at Tx, y . | Duration of disease before Tx, y . | Type of transplant . | Follow-up after transplant . |
|---|---|---|---|---|---|
| 33 | T/NK | 7 | 3 | Allo sib, MA | A 134 mo, EBV PCR− |
| 34 | NK | 24 | 2 | Allo sib, MA | D 19 d, infection, PCR− |
| 35 | T | 9 | 0.1 | Allo sib, MA | A 47 mo, PCR− |
| 36 | T | 8 | 3 | Allo, dad, MA | D 26 d, VOD, MOF, PCR+ |
| 36 | T | 5 | 4 | Allo, dad, MA | A 124 mo, PCR− |
| 37 | NK | 4 | 11 | Allo, MUD, MA | D d 14, VOD, infection, RF |
| 37 | NK | 3 | 4 | Allo, MUD, MA | A 110 mo, PCR− |
| 37 | NK | 11 | 8 | Allo, MUD, MA | A 110 mo, PCR− |
| 38 | T | 31 | 1 | Allo, sib, NMA | A 86 mo, PCR− |
| 39 | NK | 10 | 5 | Allo, sib, MA | A 24 mo, PCR− |
| 40 | T | 14 | 1 | Allo, sib, NMA | A 27 mo, PCR− |
| 41 | ND | 31 | 0.5 | Allo, sib, MA | D 3 mo, liver failure, pancreatitis, PCR− |
| 42 | T | 11 | 4 | Allo, mom, NMA | Rejection, carditis, PCR+ |
| Allo, mom, NMA | Graft failure, GVHD, PCR+ | ||||
| Unrelated cord blood | A 15 mo, GVHD, zoster, PCR− | ||||
| 43 | T | 8 | 5 | Unrelated cord blood | A 15 mo, GVHD, PCR− |
| 44 | ND | 53 | 3 | Auto HSCT | Progressed |
| Unrelated cord blood | A 16 mo, acute then chronic GVHD, PCR− | ||||
| 12 | T | 8 | 7 | Allo, mom, NMA | A 67 mo |
| 12 | T | 2 | 1 | Allo, MUD, NMA | A 23 mo |
| 12 | NK | 6 | 4 | Allo, MUD, NMA | A 13 mo |
| 12 | NK | 20 | 18 | Allo, sib, NMA | D 2 mo, relapse |
| 12 | NK | 15 | 12 | Allo, sib, MA | D 1 mo, VOD, intracranial bleed |
| 12 | ND | 31 | 27 | Allo, sib, MA | D 67 mo, DIC, acute pancreatitis |
| 12 | T | 9 | 5 | Allo, sib, MA | A 49 mo, rejection, relapse, 2nd Tx |
| 12 | NK | 9 | 5 | Allo, MUD, MA | A 12 mo |
| 12 | NK | 16 | 6 | Allo, MUD, NMA | A 57 mo |
| 12 | NK | 19 | 7 | Allo, MUD, NMA | A 9 mo |
| 12 | T | 24 | 11 | Allo, MUD, NMA | D 10 mo, relapse |
| 12 | T | 18 | 4 | Allo, sib, MA | D 1 mo, intracranial bleed |
| 12 | NK | 15 | 1 | Allo, sib, NMA | D 16 mo, relapse |
| 12 | T | 24 | 5 | Allo, MUD, NMA | D 4 mo, encephalomyelitis |
| 12 | T | 27 | 1 | Allo, MUD, NMA | A 46 mo |
| 45 | T | 30 | 0.1 | Allo, sib, NMA | A 10 mo, rejected donor T cells, reinfused donor T cells twice, PCR− |
| 46 | T | 5 | 0.5 | Allo, mom, MA | A 4 mo, PCR+ |
| 46 | NK | 2 | 0.5 | Allo, MUD, MA | A 3 mo, PCR+ |
| 47 | NK | 13 | 10 | Allo, MUD, NMA | A 27 mo, PCR− |
| 14 | T | 10 | 0.5 | Allo, MUD, MA | A 101 mo |
| 14 | T | 18 | 6 | Allo, MUD, MA | D, 35 mo |
| 14 | T | 13 | 1 | Allo, CD34, MA | D, 198 d |
| 14 | NK | 5 | 1 | Allo, MUD, MA | A, 69 mo |
| 14 | T/NK | 18 | 0.3 | Allo, rel, MA | D, 1 y |
| 14 | T | 4 | 1 | Unrelated cord blood, NMA | A, 71 mo |
| 14 | NK | 19 | 3 | Allo, rel, NMA | A, 70 mo |
| 14 | NK | 5 | 1 | Allo, rel, NMA | A, 68 mo |
| 14 | NK | 17 | 1 | Allo, CD34, NMA | D, 19 d |
| 14 | T | 7 | 1 | Allo, rel, NMA | Relapse |
| 1.75 | Allo, rel, NMA | A, 51 mo | |||
| 14 | NK | 47 | 19 | Unrelated cord blood, NMA | A, 45 mo |
| 14 | T | 19 | 0.5 | Allo, CD34, NMA | A, 43 mo |
| 14 | T | 11 | 2.5 | Unrelated cord blood, NMA | Graft failure |
| 3 | Unrelated cord blood, NMA | A, 27 mo | |||
| 14 | NK | 13.5 | 1.5 | Allo, MUD, NMA | A, 27 mo |
| 14 | T | 9 | 2 | Unrelated cord blood, NMA | A, 27 mo |
| 14 | T | 36 | 13 | Allo, rel, NMA | A, 27 mo |
| 14 | ND | 3 | 1 | Unrelated cord blood, NMA | A, 23 mo |
| 14 | NK | 10 | 3 | Unrelated cord blood, NMA | A, 22 mo |
| 14 | NK | 18.5 | 0.5 | Allo, rel, NMA | A, 21 mo |
| 14 | T/NK | 7 | 6 | Allo, MUD, NMA | A, 21 mo |
| 14 | T | 21 | 1 | Allo, MUD, NMA | A, 14 mo |
| 14 | NK | 38 | 1 | Allo, rel, NMA | A, 12 mo |
| 48 | NK | 59 | 1 | Allo, MUD, NMA | D 30 d, GI bleed, PCR+ |
| Reference . | EBV+ cells . | Age at Tx, y . | Duration of disease before Tx, y . | Type of transplant . | Follow-up after transplant . |
|---|---|---|---|---|---|
| 33 | T/NK | 7 | 3 | Allo sib, MA | A 134 mo, EBV PCR− |
| 34 | NK | 24 | 2 | Allo sib, MA | D 19 d, infection, PCR− |
| 35 | T | 9 | 0.1 | Allo sib, MA | A 47 mo, PCR− |
| 36 | T | 8 | 3 | Allo, dad, MA | D 26 d, VOD, MOF, PCR+ |
| 36 | T | 5 | 4 | Allo, dad, MA | A 124 mo, PCR− |
| 37 | NK | 4 | 11 | Allo, MUD, MA | D d 14, VOD, infection, RF |
| 37 | NK | 3 | 4 | Allo, MUD, MA | A 110 mo, PCR− |
| 37 | NK | 11 | 8 | Allo, MUD, MA | A 110 mo, PCR− |
| 38 | T | 31 | 1 | Allo, sib, NMA | A 86 mo, PCR− |
| 39 | NK | 10 | 5 | Allo, sib, MA | A 24 mo, PCR− |
| 40 | T | 14 | 1 | Allo, sib, NMA | A 27 mo, PCR− |
| 41 | ND | 31 | 0.5 | Allo, sib, MA | D 3 mo, liver failure, pancreatitis, PCR− |
| 42 | T | 11 | 4 | Allo, mom, NMA | Rejection, carditis, PCR+ |
| Allo, mom, NMA | Graft failure, GVHD, PCR+ | ||||
| Unrelated cord blood | A 15 mo, GVHD, zoster, PCR− | ||||
| 43 | T | 8 | 5 | Unrelated cord blood | A 15 mo, GVHD, PCR− |
| 44 | ND | 53 | 3 | Auto HSCT | Progressed |
| Unrelated cord blood | A 16 mo, acute then chronic GVHD, PCR− | ||||
| 12 | T | 8 | 7 | Allo, mom, NMA | A 67 mo |
| 12 | T | 2 | 1 | Allo, MUD, NMA | A 23 mo |
| 12 | NK | 6 | 4 | Allo, MUD, NMA | A 13 mo |
| 12 | NK | 20 | 18 | Allo, sib, NMA | D 2 mo, relapse |
| 12 | NK | 15 | 12 | Allo, sib, MA | D 1 mo, VOD, intracranial bleed |
| 12 | ND | 31 | 27 | Allo, sib, MA | D 67 mo, DIC, acute pancreatitis |
| 12 | T | 9 | 5 | Allo, sib, MA | A 49 mo, rejection, relapse, 2nd Tx |
| 12 | NK | 9 | 5 | Allo, MUD, MA | A 12 mo |
| 12 | NK | 16 | 6 | Allo, MUD, NMA | A 57 mo |
| 12 | NK | 19 | 7 | Allo, MUD, NMA | A 9 mo |
| 12 | T | 24 | 11 | Allo, MUD, NMA | D 10 mo, relapse |
| 12 | T | 18 | 4 | Allo, sib, MA | D 1 mo, intracranial bleed |
| 12 | NK | 15 | 1 | Allo, sib, NMA | D 16 mo, relapse |
| 12 | T | 24 | 5 | Allo, MUD, NMA | D 4 mo, encephalomyelitis |
| 12 | T | 27 | 1 | Allo, MUD, NMA | A 46 mo |
| 45 | T | 30 | 0.1 | Allo, sib, NMA | A 10 mo, rejected donor T cells, reinfused donor T cells twice, PCR− |
| 46 | T | 5 | 0.5 | Allo, mom, MA | A 4 mo, PCR+ |
| 46 | NK | 2 | 0.5 | Allo, MUD, MA | A 3 mo, PCR+ |
| 47 | NK | 13 | 10 | Allo, MUD, NMA | A 27 mo, PCR− |
| 14 | T | 10 | 0.5 | Allo, MUD, MA | A 101 mo |
| 14 | T | 18 | 6 | Allo, MUD, MA | D, 35 mo |
| 14 | T | 13 | 1 | Allo, CD34, MA | D, 198 d |
| 14 | NK | 5 | 1 | Allo, MUD, MA | A, 69 mo |
| 14 | T/NK | 18 | 0.3 | Allo, rel, MA | D, 1 y |
| 14 | T | 4 | 1 | Unrelated cord blood, NMA | A, 71 mo |
| 14 | NK | 19 | 3 | Allo, rel, NMA | A, 70 mo |
| 14 | NK | 5 | 1 | Allo, rel, NMA | A, 68 mo |
| 14 | NK | 17 | 1 | Allo, CD34, NMA | D, 19 d |
| 14 | T | 7 | 1 | Allo, rel, NMA | Relapse |
| 1.75 | Allo, rel, NMA | A, 51 mo | |||
| 14 | NK | 47 | 19 | Unrelated cord blood, NMA | A, 45 mo |
| 14 | T | 19 | 0.5 | Allo, CD34, NMA | A, 43 mo |
| 14 | T | 11 | 2.5 | Unrelated cord blood, NMA | Graft failure |
| 3 | Unrelated cord blood, NMA | A, 27 mo | |||
| 14 | NK | 13.5 | 1.5 | Allo, MUD, NMA | A, 27 mo |
| 14 | T | 9 | 2 | Unrelated cord blood, NMA | A, 27 mo |
| 14 | T | 36 | 13 | Allo, rel, NMA | A, 27 mo |
| 14 | ND | 3 | 1 | Unrelated cord blood, NMA | A, 23 mo |
| 14 | NK | 10 | 3 | Unrelated cord blood, NMA | A, 22 mo |
| 14 | NK | 18.5 | 0.5 | Allo, rel, NMA | A, 21 mo |
| 14 | T/NK | 7 | 6 | Allo, MUD, NMA | A, 21 mo |
| 14 | T | 21 | 1 | Allo, MUD, NMA | A, 14 mo |
| 14 | NK | 38 | 1 | Allo, rel, NMA | A, 12 mo |
| 48 | NK | 59 | 1 | Allo, MUD, NMA | D 30 d, GI bleed, PCR+ |
A indicates alive; Allo, allogeneic; Auto, autologous; D, dead; DIC, disseminated intravascular coagulation; GI, gastrointestinal; HSCT, hematopoietic stem cell transplant; MA, myeloablative; mo, months; MOF, multiorgan failure; MUD, matched unrelated donor; ND, not determined; NK, natural killer; NMA, nonmyeloablative; rel, related; RF, renal failure; sib, sibling; Tx, transplant; and VOD, veno-occlusive disease.