Down-regulated transcriptional pathways in CD4+ cells from patients with indolent lymphoma (n = 13) or very early CLL (n = 8) after αCD3/αCD28 stimulation
| Group/pathway . | KEGG no. . | P . | Q . |
|---|---|---|---|
| FL/eMZL | |||
| TCR signaling | 4660 | < 10−5 | < 0.001 |
| CLL | |||
| TCR signaling | 4660 | < 10−8 | < 10−6 |
| Cell adhesion molecules | 4514 | < .001 | 0.034 |
| Cytokines | 4060 | < .001 | 0.042 |
| Group/pathway . | KEGG no. . | P . | Q . |
|---|---|---|---|
| FL/eMZL | |||
| TCR signaling | 4660 | < 10−5 | < 0.001 |
| CLL | |||
| TCR signaling | 4660 | < 10−8 | < 10−6 |
| Cell adhesion molecules | 4514 | < .001 | 0.034 |
| Cytokines | 4060 | < .001 | 0.042 |
Each probe set group was analyzed with Fisher exact test against all probe sets of the HGU133Plus2.0 Affymetrix Chip and assigned to the current KEGG pathway annotation (KEGG release 52, September 2009, 358 pathways).