Causes of death
| . | ≥ 65 y (115 pts), n (%) . | < 65 y (444 pts), n (%) . | P . |
|---|---|---|---|
| Progression to AP/BP | 6 (5.2) | 15 (3.4) | .41 |
| Transplantation-related mortality | 0 | 1 (0.2) | > .999 |
| Unrelated to CML progression* | 17 (14.8) | 15 (3.4) | < .0001 |
| Other malignancy | 5 (4.3) | 10 (2.3) | .21 |
| Cardiac disease | 3 (2.6) | 2 (0.5) | .06 |
| Pulmonary embolism | 2 (1.7) | 0 | .04 |
| CNS hemorrhage | 2 (1.7) | 0 | .04 |
| Dementia | 2 (1.7) | 0 | .04 |
| Acute renal failure | 1 (0.9) | 0 | .2 |
| Chronic pulmonary disease | 1 (0.9) | 1 (0.2) | .36 |
| Infection | 1 (0.9) | 2 (0.5) | .50 |
| Total | 23 (20) | 31 (7) | .0001 |
| . | ≥ 65 y (115 pts), n (%) . | < 65 y (444 pts), n (%) . | P . |
|---|---|---|---|
| Progression to AP/BP | 6 (5.2) | 15 (3.4) | .41 |
| Transplantation-related mortality | 0 | 1 (0.2) | > .999 |
| Unrelated to CML progression* | 17 (14.8) | 15 (3.4) | < .0001 |
| Other malignancy | 5 (4.3) | 10 (2.3) | .21 |
| Cardiac disease | 3 (2.6) | 2 (0.5) | .06 |
| Pulmonary embolism | 2 (1.7) | 0 | .04 |
| CNS hemorrhage | 2 (1.7) | 0 | .04 |
| Dementia | 2 (1.7) | 0 | .04 |
| Acute renal failure | 1 (0.9) | 0 | .2 |
| Chronic pulmonary disease | 1 (0.9) | 1 (0.2) | .36 |
| Infection | 1 (0.9) | 2 (0.5) | .50 |
| Total | 23 (20) | 31 (7) | .0001 |
The proportion of patients who died as a direct consequence of CML, either for progression to AP/BP or for transplantation related mortality, was similar between older and younger patients. On the other hand, older patients died more frequently of other causes, in CP and in CHR at the time of death, with respect to younger ones.
CNS indicates central nervous system.
See “Results” for details.