The IL-1 family
| Family name . | Name . | Receptor . | Coreceptor . | Property . |
|---|---|---|---|---|
| IL-1F1 | IL-1α | IL-1RI | IL-1RacP | Proinflammatory |
| IL-1F2 | IL-1β | IL-1RI | IL-1RAcP | Proinflammatory |
| IL-1F3 | IL-1Ra | IL-1RI | NA | Antagonist for IL-1α, IL-1β |
| IL-1F4 | IL-18 | IL-18Rα | IL-18Rβ | Proinflammatory |
| IL-1F5 | IL-36Ra | IL-1Rrp2 | NA | Antagonist for IL-36α, IL-36β, IL-36γ |
| IL-1F6 | IL-36α | IL-1Rrp2 | IL-1RAcP | Proinflammatory |
| IL-1F7 | IL-37 | ?IL-18Rα* | Unknown | Anti-inflammatory |
| IL-1F8 | IL-36β | IL-1Rrp2 | IL-1RAcP | Proinflammatory |
| IL-1F9 | IL-36γ | IL-1Rrp2 | IL-1RAcP | Proinflammatory |
| IL-1F10 | IL-38 | Unknown | Unknown | Unknown |
| IL-1F11 | IL-33 | ST2 | IL-1RAcP | Th2 responses, proinflammatory |
| Family name . | Name . | Receptor . | Coreceptor . | Property . |
|---|---|---|---|---|
| IL-1F1 | IL-1α | IL-1RI | IL-1RacP | Proinflammatory |
| IL-1F2 | IL-1β | IL-1RI | IL-1RAcP | Proinflammatory |
| IL-1F3 | IL-1Ra | IL-1RI | NA | Antagonist for IL-1α, IL-1β |
| IL-1F4 | IL-18 | IL-18Rα | IL-18Rβ | Proinflammatory |
| IL-1F5 | IL-36Ra | IL-1Rrp2 | NA | Antagonist for IL-36α, IL-36β, IL-36γ |
| IL-1F6 | IL-36α | IL-1Rrp2 | IL-1RAcP | Proinflammatory |
| IL-1F7 | IL-37 | ?IL-18Rα* | Unknown | Anti-inflammatory |
| IL-1F8 | IL-36β | IL-1Rrp2 | IL-1RAcP | Proinflammatory |
| IL-1F9 | IL-36γ | IL-1Rrp2 | IL-1RAcP | Proinflammatory |
| IL-1F10 | IL-38 | Unknown | Unknown | Unknown |
| IL-1F11 | IL-33 | ST2 | IL-1RAcP | Th2 responses, proinflammatory |
NA indicates not applicable.
Question mark indicates needs confirmation.