Table 4

Distribution of patients with gain of 11q23 in subgroups defined by t(11;14) and hyperdiploidy

t (11;14) negativet (11;14) positive
AL ± MM I (n = 246)   
    Hyperdiploidy negative 13* 51 
    Hyperdiploidy positive 18 5 
MGUS/MM I (n = 180)   
    Hyperdiploidy negative 13 12 
    Hyperdiploidy positive 40 1 
t (11;14) negativet (11;14) positive
AL ± MM I (n = 246)   
    Hyperdiploidy negative 13* 51 
    Hyperdiploidy positive 18 5 
MGUS/MM I (n = 180)   
    Hyperdiploidy negative 13 12 
    Hyperdiploidy positive 40 1 
*

Three patients with a local gain of 11q23 without a concomitant gain of 11q13 (see Figure 2) are included in this number.

In patients with t(11;14) and hyperdiploidy, the clonal size of both aberrations was similar, suggesting that the same clone harbors both aberrations.

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