Genes with specific expression alterations in Sézary cells (N = 32)
| Gene . | Chromosome . | Ratio SS/Con* . | Ratio Hut78/Jurkat† . | Full name . | Function . | |
|---|---|---|---|---|---|---|
| Genes up-regulated in Sézary cells (N = 16) | ||||||
| TWIST1 | 7 | 16.9 | 11.0 | Twist homolog 1 | Regulation of transcription | |
| NEDD4L | 18 | 12.0 | 2.6 | Neural precursor cell expressed, developmentally down-regulated 4-like | Protein ubiquination | |
| CDH1 | 16 | 11.4 | 18.7 | E-cadherin | Cell adhesion | |
| PLEKHH3 | 17 | 8.6 | 2.0 | Pleckstrin homology domain containing, family H member 3 | Cell adhesion | |
| OTEX | X | 7.2 | 20.4 | Paired-like homeobox protein | Regulation of transcription | |
| TIAM2 | 6 | 7.2 | 27.5 | T-cell lymphoma invasion and metastasis 2 | Signal transduction | |
| KLF8 | X | 7.2 | 11.1 | Kruppel-like factor 8 | Regulation of transcription | |
| C14orf132 | 14 | 7.1 | 26.5 | Chromosome 14 open reading frame 132 | Unknown | |
| KCNN4 | 19 | 4.2 | 23.9 | Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 | Potassium channel | |
| EVC | 3 | 4.2 | 30.3 | Ellis van Creveld syndrome | Skeletal development | |
| GPR15 | 3 | 4.2 | 7.8 | G protein-coupled receptor 15 | Signal transduction | |
| RAPH1 | 2 | 4.1 | 1.5 | Ras association and pleckstrin homology domains 1 | Cell adhesion | |
| LMCD1 | 3 | 3.5 | 310.4 | LIM and cysteine-rich domains 1 | Ion binding | |
| ACVR2A | 2 | 3.5 | 1.5 | Activin A receptor, type IIA | Protein phosphorylation | |
| GTSF1 | 12 | 3.4 | 13.5 | Gametocyte specific factor 1 | Unknown | |
| COCH | 14 | 3.3 | 1.5 | Coagulation factor C homolog, cochlin | Unknown | |
| Genes down-regulated in Sézary cells (N = 16) | ||||||
| C21orf81 | 21 | 12.4 | 75.1 | Chromosome 21 open reading frame 81 | Unknown | |
| HOMER3 | 19 | 10.4 | 71.7 | Homer homolog 3 | Signal transduction | |
| PRSS23 | 11 | 6.8 | 1.4 | Protease, serine, 23 | Protease | |
| DNASE1L3 | 3 | 6.4 | 3.1 | Deoxyribonuclease I-like 3 | Apoptosis | |
| SYK | 9 | 6.1 | 21.3 | Spleen tyrosine kinase | Cell adhesion | |
| CR2 | 1 | 6.0 | 20.5 | Complement component (3d/Epstein Barr virus) receptor 2 | Complement activation | |
| BCL11A | 2 | 5.9 | 82.3 | B-cell CLL/lymphoma 11A | Regulation of transcription | |
| GSTP1 | 11 | 5.7 | 187.5 | Glutathione S-transferase pi | Glutathione transferase | |
| SCRN1 | 7 | 5.7 | 20.5 | Secernin 1 | Protease | |
| SGK223 | 8 | 5.6 | 6.7 | SGK223 homolog of rat pragma of Rnd2 | Protein phosphorylation | |
| CBFA2T3 | 16 | 5.5 | 41.4 | Core-binding factor, runt domain, alpha subunit 2; translocated 3 | Regulation of transcription | |
| TSPAN13 | 7 | 5.4 | 16.9 | Tetraspanin 13 | Signal transduction | |
| GPR125 | 4 | 5.3 | 825.3 | G protein-coupled receptor 125 | Signal transduction | |
| FGGY | 1 | 5.0 | 35.6 | FGGY carbohydrate kinase domain containing | Kinase activity | |
| SATB1 | 3 | 4.2 | 33.2 | Special AT-rich sequence binding protein 1 | Establishment of chromatin architecture | |
| EFNA1 | 1 | 3.6 | 21.8 | Ephrin-A1 | Signal transduction | |
| Gene . | Chromosome . | Ratio SS/Con* . | Ratio Hut78/Jurkat† . | Full name . | Function . | |
|---|---|---|---|---|---|---|
| Genes up-regulated in Sézary cells (N = 16) | ||||||
| TWIST1 | 7 | 16.9 | 11.0 | Twist homolog 1 | Regulation of transcription | |
| NEDD4L | 18 | 12.0 | 2.6 | Neural precursor cell expressed, developmentally down-regulated 4-like | Protein ubiquination | |
| CDH1 | 16 | 11.4 | 18.7 | E-cadherin | Cell adhesion | |
| PLEKHH3 | 17 | 8.6 | 2.0 | Pleckstrin homology domain containing, family H member 3 | Cell adhesion | |
| OTEX | X | 7.2 | 20.4 | Paired-like homeobox protein | Regulation of transcription | |
| TIAM2 | 6 | 7.2 | 27.5 | T-cell lymphoma invasion and metastasis 2 | Signal transduction | |
| KLF8 | X | 7.2 | 11.1 | Kruppel-like factor 8 | Regulation of transcription | |
| C14orf132 | 14 | 7.1 | 26.5 | Chromosome 14 open reading frame 132 | Unknown | |
| KCNN4 | 19 | 4.2 | 23.9 | Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 | Potassium channel | |
| EVC | 3 | 4.2 | 30.3 | Ellis van Creveld syndrome | Skeletal development | |
| GPR15 | 3 | 4.2 | 7.8 | G protein-coupled receptor 15 | Signal transduction | |
| RAPH1 | 2 | 4.1 | 1.5 | Ras association and pleckstrin homology domains 1 | Cell adhesion | |
| LMCD1 | 3 | 3.5 | 310.4 | LIM and cysteine-rich domains 1 | Ion binding | |
| ACVR2A | 2 | 3.5 | 1.5 | Activin A receptor, type IIA | Protein phosphorylation | |
| GTSF1 | 12 | 3.4 | 13.5 | Gametocyte specific factor 1 | Unknown | |
| COCH | 14 | 3.3 | 1.5 | Coagulation factor C homolog, cochlin | Unknown | |
| Genes down-regulated in Sézary cells (N = 16) | ||||||
| C21orf81 | 21 | 12.4 | 75.1 | Chromosome 21 open reading frame 81 | Unknown | |
| HOMER3 | 19 | 10.4 | 71.7 | Homer homolog 3 | Signal transduction | |
| PRSS23 | 11 | 6.8 | 1.4 | Protease, serine, 23 | Protease | |
| DNASE1L3 | 3 | 6.4 | 3.1 | Deoxyribonuclease I-like 3 | Apoptosis | |
| SYK | 9 | 6.1 | 21.3 | Spleen tyrosine kinase | Cell adhesion | |
| CR2 | 1 | 6.0 | 20.5 | Complement component (3d/Epstein Barr virus) receptor 2 | Complement activation | |
| BCL11A | 2 | 5.9 | 82.3 | B-cell CLL/lymphoma 11A | Regulation of transcription | |
| GSTP1 | 11 | 5.7 | 187.5 | Glutathione S-transferase pi | Glutathione transferase | |
| SCRN1 | 7 | 5.7 | 20.5 | Secernin 1 | Protease | |
| SGK223 | 8 | 5.6 | 6.7 | SGK223 homolog of rat pragma of Rnd2 | Protein phosphorylation | |
| CBFA2T3 | 16 | 5.5 | 41.4 | Core-binding factor, runt domain, alpha subunit 2; translocated 3 | Regulation of transcription | |
| TSPAN13 | 7 | 5.4 | 16.9 | Tetraspanin 13 | Signal transduction | |
| GPR125 | 4 | 5.3 | 825.3 | G protein-coupled receptor 125 | Signal transduction | |
| FGGY | 1 | 5.0 | 35.6 | FGGY carbohydrate kinase domain containing | Kinase activity | |
| SATB1 | 3 | 4.2 | 33.2 | Special AT-rich sequence binding protein 1 | Establishment of chromatin architecture | |
| EFNA1 | 1 | 3.6 | 21.8 | Ephrin-A1 | Signal transduction | |