Cycle 1 toxicities*
| . | Grade 1 . | Grade 2 . | Grade 3 . | Grade 4 . |
|---|---|---|---|---|
| Hematologic | ||||
| Leukopenia | 6% | 11% | 26% | 4% |
| Granulocytopenia | 6% | 13% | 17% | 9% |
| Lymphopenia | 17% | |||
| Thrombocytopenia | 28% | 4% | 15% | |
| Anemia | 13% | 21% | 6% | |
| Nonhematologic | ||||
| Fatigue | 28% | 4% | 9% | |
| Headache | 15% | 2% | ||
| Fever | 11% | 9% | ||
| Infection w/o neutropenia | 4% | 2% | ||
| Nausea | 43% | 6% | 2% | |
| Vomiting | 11% | 6% | 2% | |
| Anorexia | 17% | 4% | ||
| Dysgeusia | 4% | 2% | ||
| Constipation | 6% | 2% | ||
| Diarrhea | 9% | 2% | ||
| ECG T-wave changes | 53% | 11% | ||
| Laboratory | ||||
| Hypoalbuminemia | 15% | 4% | 2% | |
| Hyperbilirubinemia | 6% | 6% | 2% | |
| AST | 11% | 4% | 4% | |
| ALT | 9% | 4% | ||
| Hyperglycemia | 9% | 4% | ||
| Hyperuricemia | 15% | 6% | ||
| Hypocalcemia | 9% | 26% | 2% | |
| Hypokalemia | 9% | |||
| Hypomagnesemia | 9% | |||
| Hyponatremia | 9% |
| . | Grade 1 . | Grade 2 . | Grade 3 . | Grade 4 . |
|---|---|---|---|---|
| Hematologic | ||||
| Leukopenia | 6% | 11% | 26% | 4% |
| Granulocytopenia | 6% | 13% | 17% | 9% |
| Lymphopenia | 17% | |||
| Thrombocytopenia | 28% | 4% | 15% | |
| Anemia | 13% | 21% | 6% | |
| Nonhematologic | ||||
| Fatigue | 28% | 4% | 9% | |
| Headache | 15% | 2% | ||
| Fever | 11% | 9% | ||
| Infection w/o neutropenia | 4% | 2% | ||
| Nausea | 43% | 6% | 2% | |
| Vomiting | 11% | 6% | 2% | |
| Anorexia | 17% | 4% | ||
| Dysgeusia | 4% | 2% | ||
| Constipation | 6% | 2% | ||
| Diarrhea | 9% | 2% | ||
| ECG T-wave changes | 53% | 11% | ||
| Laboratory | ||||
| Hypoalbuminemia | 15% | 4% | 2% | |
| Hyperbilirubinemia | 6% | 6% | 2% | |
| AST | 11% | 4% | 4% | |
| ALT | 9% | 4% | ||
| Hyperglycemia | 9% | 4% | ||
| Hyperuricemia | 15% | 6% | ||
| Hypocalcemia | 9% | 26% | 2% | |
| Hypokalemia | 9% | |||
| Hypomagnesemia | 9% | |||
| Hyponatremia | 9% |
Toxicities occurring in cycle 1 in > 5% of patients, with an attribution of possibly, probably or definitely related to drug.