Replicated variants and their association with incident VT in the HVH and MEGA studies and in a meta-analysis
| SNP . | Gene . | Model . | OR (95% CI) . | ||
|---|---|---|---|---|---|
| HVH . | MEGA . | Meta-analysis . | |||
| rs1039084 | STXBP5 (N436S) | Additive | 0.78 (0.65-0.93) | 0.91 (0.86-0.97) | 0.90 (0.82-0.98) |
| Noncarriers | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | ||
| Heterozygotes | 0.73 (0.56-0.95) | 0.82 (0.75-0.90) | 0.81 (0.74-0.88) | ||
| Homozygotes | 0.66 (0.48-0.92) | 0.86 (0.76-0.97) | 0.83 (0.74-0.93) | ||
| rs1063856 | VWF (T789A) | Additive | 1.20 (1.01-1.42) | 1.15 (1.08-1.23) | 1.16 (1.06-1.26) |
| Noncarriers | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | ||
| Heterozygotes | 1.18 (0.92-1.51) | 1.24 (1.14-1.36) | 1.23 (1.13-1.34) | ||
| Homozygotes | 1.45 (1.00-2.07) | 1.25 (1.10-1.43) | 1.28 (1.12-1.45) | ||
| SNP . | Gene . | Model . | OR (95% CI) . | ||
|---|---|---|---|---|---|
| HVH . | MEGA . | Meta-analysis . | |||
| rs1039084 | STXBP5 (N436S) | Additive | 0.78 (0.65-0.93) | 0.91 (0.86-0.97) | 0.90 (0.82-0.98) |
| Noncarriers | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | ||
| Heterozygotes | 0.73 (0.56-0.95) | 0.82 (0.75-0.90) | 0.81 (0.74-0.88) | ||
| Homozygotes | 0.66 (0.48-0.92) | 0.86 (0.76-0.97) | 0.83 (0.74-0.93) | ||
| rs1063856 | VWF (T789A) | Additive | 1.20 (1.01-1.42) | 1.15 (1.08-1.23) | 1.16 (1.06-1.26) |
| Noncarriers | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | ||
| Heterozygotes | 1.18 (0.92-1.51) | 1.24 (1.14-1.36) | 1.23 (1.13-1.34) | ||
| Homozygotes | 1.45 (1.00-2.07) | 1.25 (1.10-1.43) | 1.28 (1.12-1.45) | ||
VT indicates venous thrombosis; HVH, Heart and Vascular Health; MEGA, Multiple Environmental and Genetic Assessment; and OR, odds ratio.