Characteristics of plasma proteins, peptides, and function in PRCPgt/gt mice
| Assay . | Wild-type . | PRCPgt/gt . | P . |
|---|---|---|---|
| Prekallikrein, % activity | 94 ± 11 | 110 ± 11 | .01 |
| Factor XII, % activity | 114 ± 49 | 69 ± 38 | .03 |
| Bradykinin, ng/mL | 0.23 ± 0.13 | 0.30 ± 0.2 | .24 |
| Angiotensin, pg/mL | 72 ± 41 | 86 ± 63 | .84 |
| Contact TGT peak, AFU | 131 ± 9 | 152 ± 9 | .02 |
| Contact TGT AUC, AFU | 18 659 ± 1255 | 22 608 ± 49 | < .01 |
| TF TGT peak, AFU | 78 ± 5 | 87 ± 5 | .06 |
| TF TGT AUC, AFU | 25 410 ± 1527 | 28 056 ± 1860 | .07 |
| Assay . | Wild-type . | PRCPgt/gt . | P . |
|---|---|---|---|
| Prekallikrein, % activity | 94 ± 11 | 110 ± 11 | .01 |
| Factor XII, % activity | 114 ± 49 | 69 ± 38 | .03 |
| Bradykinin, ng/mL | 0.23 ± 0.13 | 0.30 ± 0.2 | .24 |
| Angiotensin, pg/mL | 72 ± 41 | 86 ± 63 | .84 |
| Contact TGT peak, AFU | 131 ± 9 | 152 ± 9 | .02 |
| Contact TGT AUC, AFU | 18 659 ± 1255 | 22 608 ± 49 | < .01 |
| TF TGT peak, AFU | 78 ± 5 | 87 ± 5 | .06 |
| TF TGT AUC, AFU | 25 410 ± 1527 | 28 056 ± 1860 | .07 |
Values are mean ± SD.
Contact indicates contact activation-induced thrombin generation time; TGT, thrombin generation time; AUC, area under the curve; AFU, arbitrary fluorescent units; and TF, tissue factor.