Table 2

Inhibition of shedding by the ADAM17-specific inhibitor, BMS-561392

Protein nameAccession no.No. of transmembrane domainsPercentage inhibition
Junctional adhesion molecule (JAM-A) Q9Y5B2 100 
Ephrin B1 P98172 100 
Receptor-type tyrosine phosphatase G P23470 100 
Soluble calcium-activated nucleotidase (SCAN-1) Q8WVQ1 100 
Platelet glycoprotein IX (GPIX) P14770 100 
Tetraspanin 9 O75954 100 
Semaphorin 7A O75326 0 (GPI) 100 
Semaphorin 4D Q92854 85 
Fibrocystin-L Q86WI1 84 
Platelet glycoprotein V (GPV) P40197 64 
Platelet glycoprotein Ibα chain (GPIbα) P07359 63 
D-glucuronyl C5 epimerase O94923 55 
Trem-like transcript 1 (TLT-1) Q86YW5 51 
Syndecan 4 P31431 49 
CD226 Q15762 45 
SLAM family member 5 (CD84) QUIB8 44 
Major prion protein P04156 0 (GPI) 40 
Plexin domain-containing protein 2 (Plxdc 2) Q6UX71 33 
Chloride intracellular channel protein 4 (CLIC4) Q9Y696 32 
Integrin αIIb Q5SRI9 26 
Integrin β3 P05106 20 
CD40-L P29965 17 
CD9 P21926 17 
Dystroglycan Q14118 11 
Platelet glycoprotein VI (GPVI) Q9HCN6 
Amyloid βA4 P05067 
P-selectin P16109 
Amyloid-like protein 2 Q06481 
Chloride intracellular channel protein 1 (CLIC1) O00299 
Endothelial cell selective adhesion molecule (ESAM) Q96AP7 
Lysosome-associated membrane glycoprotein 2 (LAMP2) P13473 
Lysosomal acid phosphatase P11117 
Lysosome associated membrane glycoprotein 1 (LAMP1) P11279 
Trem-like transcript 2 (TLT-2) Q5T2D2 
Inositol monophosphatase 3 Q9NX62 
Receptor-type tyrosine phosphatase γ (CD148) Q12913 
VCAM1 P19320 
Endothelial cell scavenger receptor Q14162 
IL6 receptor P40189 
CD109 Q6YHK3 0 (GPI) 
Protein nameAccession no.No. of transmembrane domainsPercentage inhibition
Junctional adhesion molecule (JAM-A) Q9Y5B2 100 
Ephrin B1 P98172 100 
Receptor-type tyrosine phosphatase G P23470 100 
Soluble calcium-activated nucleotidase (SCAN-1) Q8WVQ1 100 
Platelet glycoprotein IX (GPIX) P14770 100 
Tetraspanin 9 O75954 100 
Semaphorin 7A O75326 0 (GPI) 100 
Semaphorin 4D Q92854 85 
Fibrocystin-L Q86WI1 84 
Platelet glycoprotein V (GPV) P40197 64 
Platelet glycoprotein Ibα chain (GPIbα) P07359 63 
D-glucuronyl C5 epimerase O94923 55 
Trem-like transcript 1 (TLT-1) Q86YW5 51 
Syndecan 4 P31431 49 
CD226 Q15762 45 
SLAM family member 5 (CD84) QUIB8 44 
Major prion protein P04156 0 (GPI) 40 
Plexin domain-containing protein 2 (Plxdc 2) Q6UX71 33 
Chloride intracellular channel protein 4 (CLIC4) Q9Y696 32 
Integrin αIIb Q5SRI9 26 
Integrin β3 P05106 20 
CD40-L P29965 17 
CD9 P21926 17 
Dystroglycan Q14118 11 
Platelet glycoprotein VI (GPVI) Q9HCN6 
Amyloid βA4 P05067 
P-selectin P16109 
Amyloid-like protein 2 Q06481 
Chloride intracellular channel protein 1 (CLIC1) O00299 
Endothelial cell selective adhesion molecule (ESAM) Q96AP7 
Lysosome-associated membrane glycoprotein 2 (LAMP2) P13473 
Lysosomal acid phosphatase P11117 
Lysosome associated membrane glycoprotein 1 (LAMP1) P11279 
Trem-like transcript 2 (TLT-2) Q5T2D2 
Inositol monophosphatase 3 Q9NX62 
Receptor-type tyrosine phosphatase γ (CD148) Q12913 
VCAM1 P19320 
Endothelial cell scavenger receptor Q14162 
IL6 receptor P40189 
CD109 Q6YHK3 0 (GPI) 

Percentage inhibition by BMS-561392 is expressed as: 1 − the ratio of spectral counts in the presence and absence of the inhibitor.

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