Inhibition of shedding by the ADAM17-specific inhibitor, BMS-561392
Protein name . | Accession no. . | No. of transmembrane domains . | Percentage inhibition . |
---|---|---|---|
Junctional adhesion molecule (JAM-A) | Q9Y5B2 | 1 | 100 |
Ephrin B1 | P98172 | 1 | 100 |
Receptor-type tyrosine phosphatase G | P23470 | 1 | 100 |
Soluble calcium-activated nucleotidase (SCAN-1) | Q8WVQ1 | 1 | 100 |
Platelet glycoprotein IX (GPIX) | P14770 | 1 | 100 |
Tetraspanin 9 | O75954 | 4 | 100 |
Semaphorin 7A | O75326 | 0 (GPI) | 100 |
Semaphorin 4D | Q92854 | 1 | 85 |
Fibrocystin-L | Q86WI1 | 1 | 84 |
Platelet glycoprotein V (GPV) | P40197 | 1 | 64 |
Platelet glycoprotein Ibα chain (GPIbα) | P07359 | 1 | 63 |
D-glucuronyl C5 epimerase | O94923 | 1 | 55 |
Trem-like transcript 1 (TLT-1) | Q86YW5 | 1 | 51 |
Syndecan 4 | P31431 | 1 | 49 |
CD226 | Q15762 | 1 | 45 |
SLAM family member 5 (CD84) | QUIB8 | 1 | 44 |
Major prion protein | P04156 | 0 (GPI) | 40 |
Plexin domain-containing protein 2 (Plxdc 2) | Q6UX71 | 1 | 33 |
Chloride intracellular channel protein 4 (CLIC4) | Q9Y696 | 1 | 32 |
Integrin αIIb | Q5SRI9 | 1 | 26 |
Integrin β3 | P05106 | 1 | 20 |
CD40-L | P29965 | 1 | 17 |
CD9 | P21926 | 4 | 17 |
Dystroglycan | Q14118 | 1 | 11 |
Platelet glycoprotein VI (GPVI) | Q9HCN6 | 1 | 2 |
Amyloid βA4 | P05067 | 1 | 0 |
P-selectin | P16109 | 1 | 0 |
Amyloid-like protein 2 | Q06481 | 1 | 0 |
Chloride intracellular channel protein 1 (CLIC1) | O00299 | 1 | 0 |
Endothelial cell selective adhesion molecule (ESAM) | Q96AP7 | 1 | 0 |
Lysosome-associated membrane glycoprotein 2 (LAMP2) | P13473 | 1 | 0 |
Lysosomal acid phosphatase | P11117 | 1 | 0 |
Lysosome associated membrane glycoprotein 1 (LAMP1) | P11279 | 1 | 0 |
Trem-like transcript 2 (TLT-2) | Q5T2D2 | 1 | 0 |
Inositol monophosphatase 3 | Q9NX62 | 1 | 0 |
Receptor-type tyrosine phosphatase γ (CD148) | Q12913 | 1 | 0 |
VCAM1 | P19320 | 1 | 0 |
Endothelial cell scavenger receptor | Q14162 | 1 | 0 |
IL6 receptor | P40189 | 1 | 0 |
CD109 | Q6YHK3 | 0 (GPI) | 0 |
Protein name . | Accession no. . | No. of transmembrane domains . | Percentage inhibition . |
---|---|---|---|
Junctional adhesion molecule (JAM-A) | Q9Y5B2 | 1 | 100 |
Ephrin B1 | P98172 | 1 | 100 |
Receptor-type tyrosine phosphatase G | P23470 | 1 | 100 |
Soluble calcium-activated nucleotidase (SCAN-1) | Q8WVQ1 | 1 | 100 |
Platelet glycoprotein IX (GPIX) | P14770 | 1 | 100 |
Tetraspanin 9 | O75954 | 4 | 100 |
Semaphorin 7A | O75326 | 0 (GPI) | 100 |
Semaphorin 4D | Q92854 | 1 | 85 |
Fibrocystin-L | Q86WI1 | 1 | 84 |
Platelet glycoprotein V (GPV) | P40197 | 1 | 64 |
Platelet glycoprotein Ibα chain (GPIbα) | P07359 | 1 | 63 |
D-glucuronyl C5 epimerase | O94923 | 1 | 55 |
Trem-like transcript 1 (TLT-1) | Q86YW5 | 1 | 51 |
Syndecan 4 | P31431 | 1 | 49 |
CD226 | Q15762 | 1 | 45 |
SLAM family member 5 (CD84) | QUIB8 | 1 | 44 |
Major prion protein | P04156 | 0 (GPI) | 40 |
Plexin domain-containing protein 2 (Plxdc 2) | Q6UX71 | 1 | 33 |
Chloride intracellular channel protein 4 (CLIC4) | Q9Y696 | 1 | 32 |
Integrin αIIb | Q5SRI9 | 1 | 26 |
Integrin β3 | P05106 | 1 | 20 |
CD40-L | P29965 | 1 | 17 |
CD9 | P21926 | 4 | 17 |
Dystroglycan | Q14118 | 1 | 11 |
Platelet glycoprotein VI (GPVI) | Q9HCN6 | 1 | 2 |
Amyloid βA4 | P05067 | 1 | 0 |
P-selectin | P16109 | 1 | 0 |
Amyloid-like protein 2 | Q06481 | 1 | 0 |
Chloride intracellular channel protein 1 (CLIC1) | O00299 | 1 | 0 |
Endothelial cell selective adhesion molecule (ESAM) | Q96AP7 | 1 | 0 |
Lysosome-associated membrane glycoprotein 2 (LAMP2) | P13473 | 1 | 0 |
Lysosomal acid phosphatase | P11117 | 1 | 0 |
Lysosome associated membrane glycoprotein 1 (LAMP1) | P11279 | 1 | 0 |
Trem-like transcript 2 (TLT-2) | Q5T2D2 | 1 | 0 |
Inositol monophosphatase 3 | Q9NX62 | 1 | 0 |
Receptor-type tyrosine phosphatase γ (CD148) | Q12913 | 1 | 0 |
VCAM1 | P19320 | 1 | 0 |
Endothelial cell scavenger receptor | Q14162 | 1 | 0 |
IL6 receptor | P40189 | 1 | 0 |
CD109 | Q6YHK3 | 0 (GPI) | 0 |
Percentage inhibition by BMS-561392 is expressed as: 1 − the ratio of spectral counts in the presence and absence of the inhibitor.