Changes in gene expression induced by hypoxia at 1% O2 for 24 hours
| Cluster/gene . | Induction, -fold . |
|---|---|
| HIF target genes | |
| EPO | 11.1 |
| Adrenomedullin | 3.9 |
| Vascular endothelial growth factor | 2.8 |
| Lysyl oxidase | 3.1 |
| Carbonic anhydrase IX | 10.9 |
| Fibroblast markers | |
| Ecto-5′-nucleotidase CD73 | 0.4 |
| Procollagen-proline-4-hydroxylase | 1.2 |
| Procollagen-lysine-2-hydroxylase | 3.5 |
| Collagen type V | 1.4 |
| Collagen type III | 1.2 |
| FGFR1 | 0.6 |
| FGFR2 | 0.7 |
| Transcription factors | |
| HIF-1α | 0.7 |
| HIF-2α | 2.5 |
| ARNT | 0 |
| HNF4α | 1.8 |
| Neuronal markers | |
| Enolase 2 | 30.9 |
| Neural precursor cell protein (↓E9) | 2.7 |
| Brain-expressed X-linked 1 | 0.5 |
| GABA-receptor–associated protein 2 | 1.5 |
| vMAP-2 | 0.6 |
| NF-L (68 kDa) | 0.5 |
| Neurogenic differentiation 4 | 0.3 |
| Cluster/gene . | Induction, -fold . |
|---|---|
| HIF target genes | |
| EPO | 11.1 |
| Adrenomedullin | 3.9 |
| Vascular endothelial growth factor | 2.8 |
| Lysyl oxidase | 3.1 |
| Carbonic anhydrase IX | 10.9 |
| Fibroblast markers | |
| Ecto-5′-nucleotidase CD73 | 0.4 |
| Procollagen-proline-4-hydroxylase | 1.2 |
| Procollagen-lysine-2-hydroxylase | 3.5 |
| Collagen type V | 1.4 |
| Collagen type III | 1.2 |
| FGFR1 | 0.6 |
| FGFR2 | 0.7 |
| Transcription factors | |
| HIF-1α | 0.7 |
| HIF-2α | 2.5 |
| ARNT | 0 |
| HNF4α | 1.8 |
| Neuronal markers | |
| Enolase 2 | 30.9 |
| Neural precursor cell protein (↓E9) | 2.7 |
| Brain-expressed X-linked 1 | 0.5 |
| GABA-receptor–associated protein 2 | 1.5 |
| vMAP-2 | 0.6 |
| NF-L (68 kDa) | 0.5 |
| Neurogenic differentiation 4 | 0.3 |