Table 2

Functional grouping of differentially expressed genes

Functional group/geneFold differencePSignificance
Interferon response    
    PYHIN1 (IFIX), (growth interferon-inducible protein X) 2.8 .000052 Interferon-inducible HIN-200 gene family member17  
    MNDA (myeloid nuclear differentiation antigen) 2.2 .0092 HIN-200 gene family member17,19  
    OAS1 (2′, 5′ oligoadenylate cyclase) 2.1 .000052 IFN-inducible gene which activates RNaseL 
B-cell anergy    
    LGALS1 (galectin-1) 3.6 .00038 Negatively regulates B-cell proliferation upon BCR ligation14 ; up-regulated in anergic murine B cells12  
    CD200R1 (CD200 receptor 1) 2.4 .0034 Inhibitory receptor highly expressed on memory B cells and plasmablasts; definitive role in B cell activation not established11  
    LAX1 (lymphocyte transmembrane adapter 1) 2.1 .032 Dampens B-cell response to BCR engagement16  
B-cell apoptosis    
    LGALS1 3.6 .00038 Expressed in IgM+ memory cells, reported to enhance apoptosis via inhibition of Akt phosphorylation and up-regulation of Bim13  
    PYHIN1 2.8 .000052 As an HIN-200 gene family member, contains an N-terminal PAAD/DAPIN/Pyrin domain that mediates binding with proteins involved in apoptotic NF-κB and caspase signaling17  
    DAPK2 (death-associated protein kinase 2) 2.4 .043 Calcium/calmodulin-dependent protein kinase, which induces apoptosis15  
    MNDA 2.2 .0092 As an HIN-200 gene family member, contains an N-terminal PAAD/DAPIN/Pyrin domain that mediates binding with proteins involved in apoptotic NF-κB and caspase signaling17  
B-cell survival    
    TCL1A (T-cell lymphoma antigen 1A) 0.34 .000075 Reported to enhance B-cell survival by induction of Mcl-113  
B-cell lymphomagenesis    
    SOX5 (SRY-box 5) 3.6 .00062 Reported to be up-regulated in splenic follicular lymphoma20  
    ITGAX, (CD11C), (integrin, α X) 2.9 .00066 High expression associated with splenic marginal zone lymphoma21  
    MNDA 2.2 .0092 Expressed in marginal zone B cells, up-regulated in marginal zone lymphoma22  
    BACH2 0.46 .022 Down-regulated in Waldenström macroglobulinemia10  
    FOXP1 0.44 .00072 Up-regulation of FOXP1 in mucosa-associated lymphoid tissue lymphoma may be associated with neoplastic transformation23  
    TCL1A (T-cell lymphoma 1A) 0.34 .00075 Up-regulated in splenic marginal zone lymphoma18  
    SELL (L-selectin) 0.34 .00031 Up-regulated in splenic marginal zone lymphoma18  
    IL-4R (IL-4 receptor) 0.31 .00017 Down-regulated in mantle cell lymphoma and Waldenström macroglobulinemia10  
    LMO2 (LIM domain only 2) 0.31 .0010 Up-regulation corresponds to increased survival in diffuse large B-cell lymphoma24  
Functional group/geneFold differencePSignificance
Interferon response    
    PYHIN1 (IFIX), (growth interferon-inducible protein X) 2.8 .000052 Interferon-inducible HIN-200 gene family member17  
    MNDA (myeloid nuclear differentiation antigen) 2.2 .0092 HIN-200 gene family member17,19  
    OAS1 (2′, 5′ oligoadenylate cyclase) 2.1 .000052 IFN-inducible gene which activates RNaseL 
B-cell anergy    
    LGALS1 (galectin-1) 3.6 .00038 Negatively regulates B-cell proliferation upon BCR ligation14 ; up-regulated in anergic murine B cells12  
    CD200R1 (CD200 receptor 1) 2.4 .0034 Inhibitory receptor highly expressed on memory B cells and plasmablasts; definitive role in B cell activation not established11  
    LAX1 (lymphocyte transmembrane adapter 1) 2.1 .032 Dampens B-cell response to BCR engagement16  
B-cell apoptosis    
    LGALS1 3.6 .00038 Expressed in IgM+ memory cells, reported to enhance apoptosis via inhibition of Akt phosphorylation and up-regulation of Bim13  
    PYHIN1 2.8 .000052 As an HIN-200 gene family member, contains an N-terminal PAAD/DAPIN/Pyrin domain that mediates binding with proteins involved in apoptotic NF-κB and caspase signaling17  
    DAPK2 (death-associated protein kinase 2) 2.4 .043 Calcium/calmodulin-dependent protein kinase, which induces apoptosis15  
    MNDA 2.2 .0092 As an HIN-200 gene family member, contains an N-terminal PAAD/DAPIN/Pyrin domain that mediates binding with proteins involved in apoptotic NF-κB and caspase signaling17  
B-cell survival    
    TCL1A (T-cell lymphoma antigen 1A) 0.34 .000075 Reported to enhance B-cell survival by induction of Mcl-113  
B-cell lymphomagenesis    
    SOX5 (SRY-box 5) 3.6 .00062 Reported to be up-regulated in splenic follicular lymphoma20  
    ITGAX, (CD11C), (integrin, α X) 2.9 .00066 High expression associated with splenic marginal zone lymphoma21  
    MNDA 2.2 .0092 Expressed in marginal zone B cells, up-regulated in marginal zone lymphoma22  
    BACH2 0.46 .022 Down-regulated in Waldenström macroglobulinemia10  
    FOXP1 0.44 .00072 Up-regulation of FOXP1 in mucosa-associated lymphoid tissue lymphoma may be associated with neoplastic transformation23  
    TCL1A (T-cell lymphoma 1A) 0.34 .00075 Up-regulated in splenic marginal zone lymphoma18  
    SELL (L-selectin) 0.34 .00031 Up-regulated in splenic marginal zone lymphoma18  
    IL-4R (IL-4 receptor) 0.31 .00017 Down-regulated in mantle cell lymphoma and Waldenström macroglobulinemia10  
    LMO2 (LIM domain only 2) 0.31 .0010 Up-regulation corresponds to increased survival in diffuse large B-cell lymphoma24  

IFN indicates interferon; PAAD/DAPIN, Pyrin, AIM (Absent in Melanoma), ASC (Apoptosis-associated-speck-like protein containing a caspase recruitment domain [CARD]) and death-domain (DD)-like Domain in Apoptosis and Interferon response; and NFκB, nuclear factor-κB.

*

Bonferroni corrected.

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