Characteristics of HUS patients included in this study
| Patient . | Sex . | Age at diagnosis, y . | Prodromal diarrhea . | Laboratory findings . | Extrarenal symptoms . | E coli serotype§ . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hemolytic anemia,* hemoglobin (lowest), g/L . | Platelet count × 109 (lowest), ref 140-400 . | Renal failure . | Complement levels . | |||||||||
| Creatinine (highest), μmol/L† . | Urea (highest), mmol/L‡ . | Duration of peritoneal dialysis . | C3, g/L (ref (0.77-1.38) . | C4, g/L (ref (0.12-0.33) . | ||||||||
| 1 | M | 3 | +¶ | 62 | 21 | 103 | 15.6 | NA | NA | O157 | ||
| 2 | M | 3 | +¶ | 72 | 44 | 48 | 5.1 | NA | NA | O157 | ||
| 3 | M | 7 | + | 56 | 18 | 453 | 27.8 | 17 d | 1.11 | 0.16 | O157 | |
| 4 | M | 1 | + | 58 | 27 | 88 | 16.3 | 0.96 | 0.22 | O26 | ||
| 5 | F | 3 | +¶ | 63 | 35 | 286 | 21.1 | 21 d# | 0.79 | 0.05** | Rectal prolapse | O157 |
| 6 | F | 2 | + | 43 | 10 | 96 | 16.7 | 1.21 | 0.16 | Rectal prolapse | O157 | |
| 7 | M | 2 | +¶ | 63 | 31 | 174 | 17.3 | 1.01 | 0.18 | O145 | ||
| 8 | M | 10 | + | 49 | 35 | 468 | 37.5 | 10 d | 1.02 | 0.21 | O157 | |
| 9 | F | 2 | +¶ | 57 | < 10 | 64 | 10.9 | NA | NA | O157 | ||
| 10 | F | 11 | +¶ | 55 | 27 | 280 | 28.2 | 1.26 | 0.14 | O157 | ||
| 11 | M | 10 | +¶ | 41 | 30 | 379 | 28.3 | 15 d | 1.08 | 0.15 | Coma, hemiplegia, seizures | O157 |
| 12 | M | 5 | +¶ | 66 | < 10 | 188 | 20.6 | 4 d | 0.95 | 0.06** | O157 | |
| Patient . | Sex . | Age at diagnosis, y . | Prodromal diarrhea . | Laboratory findings . | Extrarenal symptoms . | E coli serotype§ . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hemolytic anemia,* hemoglobin (lowest), g/L . | Platelet count × 109 (lowest), ref 140-400 . | Renal failure . | Complement levels . | |||||||||
| Creatinine (highest), μmol/L† . | Urea (highest), mmol/L‡ . | Duration of peritoneal dialysis . | C3, g/L (ref (0.77-1.38) . | C4, g/L (ref (0.12-0.33) . | ||||||||
| 1 | M | 3 | +¶ | 62 | 21 | 103 | 15.6 | NA | NA | O157 | ||
| 2 | M | 3 | +¶ | 72 | 44 | 48 | 5.1 | NA | NA | O157 | ||
| 3 | M | 7 | + | 56 | 18 | 453 | 27.8 | 17 d | 1.11 | 0.16 | O157 | |
| 4 | M | 1 | + | 58 | 27 | 88 | 16.3 | 0.96 | 0.22 | O26 | ||
| 5 | F | 3 | +¶ | 63 | 35 | 286 | 21.1 | 21 d# | 0.79 | 0.05** | Rectal prolapse | O157 |
| 6 | F | 2 | + | 43 | 10 | 96 | 16.7 | 1.21 | 0.16 | Rectal prolapse | O157 | |
| 7 | M | 2 | +¶ | 63 | 31 | 174 | 17.3 | 1.01 | 0.18 | O145 | ||
| 8 | M | 10 | + | 49 | 35 | 468 | 37.5 | 10 d | 1.02 | 0.21 | O157 | |
| 9 | F | 2 | +¶ | 57 | < 10 | 64 | 10.9 | NA | NA | O157 | ||
| 10 | F | 11 | +¶ | 55 | 27 | 280 | 28.2 | 1.26 | 0.14 | O157 | ||
| 11 | M | 10 | +¶ | 41 | 30 | 379 | 28.3 | 15 d | 1.08 | 0.15 | Coma, hemiplegia, seizures | O157 |
| 12 | M | 5 | +¶ | 66 | < 10 | 188 | 20.6 | 4 d | 0.95 | 0.06** | O157 | |
NA indicates not available.
Hemolytic anemia was defined as hemoglobin levels < 100 g/L, elevated reticulocyte counts, elevated lactic dehydrogenase, and unconjugated bilirubin. All patients had a negative direct antiglobulin test.
Reference value < 5 years: 14-37μM; 5-15 years: 25-68μM.
Reference value < 5 years: 1.7-5.0mM; 5-16 years: 1.7-7.3mM.
All strains produced Stx2.
Bloody diarrhea.
Due to peritonitis also treated with hemodialysis.
C4 level normalized after 10 days.