Cohort-specific association results for fibrinogen gene SNPs in EAs
| SNP . | Gene . | ARIC N = 9554 . | CARDIA N = 1311 . | CFS N = 252 . | CHS N = 3918 . | FHS N = 6733 . | MESA N = 2288 . | P for between-study heterogeneity . |
|---|---|---|---|---|---|---|---|---|
| rs1800787 | FGB | 0.132 ± 0.018 P = 1 × 10−13 | 0.164 ± 0.04 P = .0004 | NA | 0.150 ± 0.027 P = 3 × 10−8 | 0.178 ± 0.023 P = 2 × 10−14 | 0.159 ± 0.037 P = 2 × 10−5 | .62 |
| rs6054 | FGB | −0.588 ± 0.112 P = 1 × 10−7 | −0.904 ± 0.350 P = .01 | NA | −0.648 ± 0.192 P = .0007 | −0.526 ± 0.111 P=2 × 10−6 | −0.545 ± 0.0218 P = .013 | .87 |
| rs2066861 | FGG | −0.116 ± 0.017 P = 8 × 10−12 | −0.0588 ± 0.045 P = .20 | 0.0224 ± 0.115 P = .85 | −0.159 ± 0.02 P=1 × 10−9 | 0.0216 ± 0.02 P = .33 | 0.057 ± 0.03 P = .11 | 1.48 × 10−9 |
| SNP . | Gene . | ARIC N = 9554 . | CARDIA N = 1311 . | CFS N = 252 . | CHS N = 3918 . | FHS N = 6733 . | MESA N = 2288 . | P for between-study heterogeneity . |
|---|---|---|---|---|---|---|---|---|
| rs1800787 | FGB | 0.132 ± 0.018 P = 1 × 10−13 | 0.164 ± 0.04 P = .0004 | NA | 0.150 ± 0.027 P = 3 × 10−8 | 0.178 ± 0.023 P = 2 × 10−14 | 0.159 ± 0.037 P = 2 × 10−5 | .62 |
| rs6054 | FGB | −0.588 ± 0.112 P = 1 × 10−7 | −0.904 ± 0.350 P = .01 | NA | −0.648 ± 0.192 P = .0007 | −0.526 ± 0.111 P=2 × 10−6 | −0.545 ± 0.0218 P = .013 | .87 |
| rs2066861 | FGG | −0.116 ± 0.017 P = 8 × 10−12 | −0.0588 ± 0.045 P = .20 | 0.0224 ± 0.115 P = .85 | −0.159 ± 0.02 P=1 × 10−9 | 0.0216 ± 0.02 P = .33 | 0.057 ± 0.03 P = .11 | 1.48 × 10−9 |
For each study, the number in the top row indicate regression β coefficient for standardized fibrinogen ± standard error, based on an additive genetic model. The last column indicates the P value for heterogeneity based on the combined meta-analysis.