Soluble IL-2Rα (CD25) levels detected in the serum of rhesus macaques receiving 12 daily infusions of rhIL-15
| Macaque ID . | rhIL-15 dose, μg/kg . | Soluble IL-2Rα level, pg/mL . | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Pre-therapy . | Day 2 . | Day 8 . | Day 13 . | Day 15 . | Day 22 . | Day 29 . | Day 48 . | ||
| 395 | Vehicle | 356 | ND | 394 | 390 | ND | ND | ND | ND |
| CFIT | Vehicle | 769 | ND | 668 | 770 | ND | ND | ND | ND |
| XDD | Vehicle | 422 | ND | 768 | 481 | ND | ND | ND | ND |
| Mean | 516 | 610 | 547 | ||||||
| SD | 222 | 194 | 198 | ||||||
| XFH | 10 | 681 | 1643 | 2753 | 2792 | ND | ND | ND | ND |
| DA5F | 10 | 1388 | 2663 | 2842 | 3259 | ND | ND | ND | ND |
| CF5F | 10 | 581 | 1861 | 1623 | 1506 | ND | ND | ND | ND |
| 446 | 10 | 388 | ND | 2118 | ND | 1874 | 705 | 716 | 334 |
| XDT | 10 | 488 | ND | 1103 | ND | 777 | 414 | 439 | 415 |
| CJ5P | 10 | 645 | ND | 2336 | ND | 1646 | 844 | 969 | 703 |
| Mean | 695 | 2056 | 2129 | 2519 | 1432 | 654 | 708 | 484 | |
| SD | 356 | 537 | 671 | 908 | 579 | 219 | 265 | 194 | |
| RQ3552 | 20 | 1056 | 1556 | 2194 | 2860 | ND | ND | ND | ND |
| H450 | 20 | 435 | 1234 | 1971 | 2485 | ND | ND | ND | ND |
| CK3D | 20 | 351 | 998 | 1658 | 1917 | ND | ND | ND | ND |
| VCT | 20 | 942 | ND | 3167 | ND | 2033 | 965 | 750 | 839 |
| VVX | 20 | 754 | ND | 3523 | ND | 1971 | 938 | 755 | 590 |
| CK2X | 20 | 774 | ND | 1858 | ND | 1237 | 645 | 683 | 599 |
| Mean | 719 | 1263 | 2395 | 2421 | 1747 | 849 | 729 | 676 | |
| SD | 277 | 280 | 764 | 475 | 443 | 177 | 40 | 141 | |
| CJ64 | 50 | 962 | 2751 | 6726 | 6885 | ND | ND | ND | ND |
| OIE123 | 50 | 512 | 1173 | 3794 | 4885 | ND | ND | ND | ND |
| CF65 | 50 | 1080 | 1843 | 7910 | 6041 | ND | ND | ND | ND |
| XFK | 50 | 349 | ND | 3934 | ND | 1914 | 615 | 458 | 378 |
| CK18 | 50 | 814 | ND | 3805 | ND | 2076 | 892 | 697 | 718 |
| CF4C | 50 | 602 | ND | 4349 | ND | 3052 | 932 | 663 | 632 |
| Mean | 720 | 1922 | 5086 | 5937 | 2347 | 813 | 606 | 576 | |
| SD | 280 | 792 | 1780 | 1004 | 616 | 173 | 129 | 177 | |
| Macaque ID . | rhIL-15 dose, μg/kg . | Soluble IL-2Rα level, pg/mL . | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Pre-therapy . | Day 2 . | Day 8 . | Day 13 . | Day 15 . | Day 22 . | Day 29 . | Day 48 . | ||
| 395 | Vehicle | 356 | ND | 394 | 390 | ND | ND | ND | ND |
| CFIT | Vehicle | 769 | ND | 668 | 770 | ND | ND | ND | ND |
| XDD | Vehicle | 422 | ND | 768 | 481 | ND | ND | ND | ND |
| Mean | 516 | 610 | 547 | ||||||
| SD | 222 | 194 | 198 | ||||||
| XFH | 10 | 681 | 1643 | 2753 | 2792 | ND | ND | ND | ND |
| DA5F | 10 | 1388 | 2663 | 2842 | 3259 | ND | ND | ND | ND |
| CF5F | 10 | 581 | 1861 | 1623 | 1506 | ND | ND | ND | ND |
| 446 | 10 | 388 | ND | 2118 | ND | 1874 | 705 | 716 | 334 |
| XDT | 10 | 488 | ND | 1103 | ND | 777 | 414 | 439 | 415 |
| CJ5P | 10 | 645 | ND | 2336 | ND | 1646 | 844 | 969 | 703 |
| Mean | 695 | 2056 | 2129 | 2519 | 1432 | 654 | 708 | 484 | |
| SD | 356 | 537 | 671 | 908 | 579 | 219 | 265 | 194 | |
| RQ3552 | 20 | 1056 | 1556 | 2194 | 2860 | ND | ND | ND | ND |
| H450 | 20 | 435 | 1234 | 1971 | 2485 | ND | ND | ND | ND |
| CK3D | 20 | 351 | 998 | 1658 | 1917 | ND | ND | ND | ND |
| VCT | 20 | 942 | ND | 3167 | ND | 2033 | 965 | 750 | 839 |
| VVX | 20 | 754 | ND | 3523 | ND | 1971 | 938 | 755 | 590 |
| CK2X | 20 | 774 | ND | 1858 | ND | 1237 | 645 | 683 | 599 |
| Mean | 719 | 1263 | 2395 | 2421 | 1747 | 849 | 729 | 676 | |
| SD | 277 | 280 | 764 | 475 | 443 | 177 | 40 | 141 | |
| CJ64 | 50 | 962 | 2751 | 6726 | 6885 | ND | ND | ND | ND |
| OIE123 | 50 | 512 | 1173 | 3794 | 4885 | ND | ND | ND | ND |
| CF65 | 50 | 1080 | 1843 | 7910 | 6041 | ND | ND | ND | ND |
| XFK | 50 | 349 | ND | 3934 | ND | 1914 | 615 | 458 | 378 |
| CK18 | 50 | 814 | ND | 3805 | ND | 2076 | 892 | 697 | 718 |
| CF4C | 50 | 602 | ND | 4349 | ND | 3052 | 932 | 663 | 632 |
| Mean | 720 | 1922 | 5086 | 5937 | 2347 | 813 | 606 | 576 | |
| SD | 280 | 792 | 1780 | 1004 | 616 | 173 | 129 | 177 | |
ND indicates not determined.