Table 1

Data analysis of rhIL-15 pharmacokinetic studies performed in rhesus macaques after the first or last of 12 daily infusions at 10, 20, or 50 μg/kg/d

Parameter, unitsStudy day 1
Study day 12
10 μg/kg/d
20 μg/kg/d
50 μg/kg/d
10 μg/kg/d
20 μg/kg/d
50 μg/kg/d
MeanSDMeanSDMeanSDMeanSDMeanSDMeanSD
Cmax, ng/mL 475.4 36.7 584.9 281 1994.7 421 450.7 70.9 460.9 358.9 1705.6 554.3 
AUC0-4 h, ng·h/mL 147.0 36.3 260.3 91.0 719.4 149 138.9 16.2 155.6 34.2 641.9 69.1 
Terminal slope, h−1 0.642 0.13 0.639 0.08 0.772 0.08 0.694 0.36 0.678 0.12 0.71 0.15 
Half-life, h 1.113 0.25 1.101 0.16 0.907 0.11 1.315 0.93 1.039 0.19 2.159 1.29 
AUCinf, ng·h/mL 151.4 36.4 269.6 95.6 733.5 149 147.5 12.7 161.3 30.6 660.9 95.1 
AUCinf/dose, ng·h/mL/μg 15.14 3.64 13.48 4.78 14.67 2.98 14.75 1.27 12.04 7.61 13.22 1.90 
CL, L/h/kg 0.069 0.02 0.082 0.03 0.070 0.01 0.068 0.01 0.0832 0.04 0.076 0.01 
Vss, L/kg 0.050 0.01 0.063 0.02 0.047 0.01 0.044 0.04 0.06 0.06 0.043 0.014 
Parameter, unitsStudy day 1
Study day 12
10 μg/kg/d
20 μg/kg/d
50 μg/kg/d
10 μg/kg/d
20 μg/kg/d
50 μg/kg/d
MeanSDMeanSDMeanSDMeanSDMeanSDMeanSD
Cmax, ng/mL 475.4 36.7 584.9 281 1994.7 421 450.7 70.9 460.9 358.9 1705.6 554.3 
AUC0-4 h, ng·h/mL 147.0 36.3 260.3 91.0 719.4 149 138.9 16.2 155.6 34.2 641.9 69.1 
Terminal slope, h−1 0.642 0.13 0.639 0.08 0.772 0.08 0.694 0.36 0.678 0.12 0.71 0.15 
Half-life, h 1.113 0.25 1.101 0.16 0.907 0.11 1.315 0.93 1.039 0.19 2.159 1.29 
AUCinf, ng·h/mL 151.4 36.4 269.6 95.6 733.5 149 147.5 12.7 161.3 30.6 660.9 95.1 
AUCinf/dose, ng·h/mL/μg 15.14 3.64 13.48 4.78 14.67 2.98 14.75 1.27 12.04 7.61 13.22 1.90 
CL, L/h/kg 0.069 0.02 0.082 0.03 0.070 0.01 0.068 0.01 0.0832 0.04 0.076 0.01 
Vss, L/kg 0.050 0.01 0.063 0.02 0.047 0.01 0.044 0.04 0.06 0.06 0.043 0.014 

AUC0-4 h indicates area under the curve; AUCinf, inferred AUC; CL, clearance; and Vss, volume of distribution at steady state.

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