Table 5 Grade 3 and 4 toxicities,... | American Society of Hematology

Table 5

Grade 3 and 4 toxicities, according to WHO grading system, observed during consolidation

Toxicity	First cycle (n = 749 patients), no. (%)	Second cycle (n = 730 patients), no. (%)	Third cycle (n = 683 patients), no. (%)	P
Hemorrhage	3 (0.40)	5 (0.69)	4 (0.59)	.7693
Liver	4 (0.53)	7 (0.96)	4 (0.59)	.6156
Renal	0	0	2 (0.29)	.0997
Cardiac rhythm	0	2 (0.27)	0	.2136
Cardiac function	1 (0.13)	3 (0.41)	0	.2776
Oral mucositis	2 (0.27)	27 (3.70)	4 (0.59)	< .0001*
Nausea/vomiting	5 (0.67)	8 (1.10)	7 (1.02)	.6542
Diarrhea	1 (0.13)	2 (0.27)	2 (0.29)	.7485
Total	16	54	23	< .0001†

Toxicity	First cycle (n = 749 patients), no. (%)	Second cycle (n = 730 patients), no. (%)	Third cycle (n = 683 patients), no. (%)	P
Hemorrhage	3 (0.40)	5 (0.69)	4 (0.59)	.7693
Liver	4 (0.53)	7 (0.96)	4 (0.59)	.6156
Renal	0	0	2 (0.29)	.0997
Cardiac rhythm	0	2 (0.27)	0	.2136
Cardiac function	1 (0.13)	3 (0.41)	0	.2776
Oral mucositis	2 (0.27)	27 (3.70)	4 (0.59)	< .0001*
Nausea/vomiting	5 (0.67)	8 (1.10)	7 (1.02)	.6542
Diarrhea	1 (0.13)	2 (0.27)	2 (0.29)	.7485
Total	16	54	23	< .0001†

First cycle vs second cycle (P < .0001), second cycle vs third cycle (P < .0001), and first cycle vs third cycle (P = .4332).

First cycle vs second cycle (P < .0001), second cycle vs third cycle (P = .0009), and first cycle vs third cycle (P = .1568).