RAS definitely present or indeterminate before and after December 1996
| . | No. of patients evaluable for RAS . | RAS definitely present or indeterminate, no. (%) . | No RAS, no. (%) . | P . |
|---|---|---|---|---|
| Before | 263 | 50 (19) | 213 (81) | |
| After | 534 | 61 (11.4) | 473 (88.6) | |
| .0036 |
| . | No. of patients evaluable for RAS . | RAS definitely present or indeterminate, no. (%) . | No RAS, no. (%) . | P . |
|---|---|---|---|---|
| Before | 263 | 50 (19) | 213 (81) | |
| After | 534 | 61 (11.4) | 473 (88.6) | |
| .0036 |
In December 1996 the protocol was amended and methylprednisolone was introduced as prophylaxis of RAS.
Definitely present indicates the presence of the following 5 signs and symptoms: fever, dyspnea, pleural and/or pericardial effusion, pulmonary infiltrates on chest radiograph, and weight gain; and indeterminate, the presence of a combination of 2 to 4 of these signs and symptoms associated or not with lower extremity edema and/or hypotension.